李志宏 ,M.D., PhD. 
單位: 高雄長庚紀念醫院/長庚大學
現職:
- 長庚醫院學術組教授
- 長庚醫院皮膚科主治醫師
- 長庚醫院醫師研究員
- 國際乾癬網絡台灣代表
- 台灣研究皮膚科學會常務理事
- 國際醫學地質學會台灣分會會員委員會主席
聯絡地址:
83301高雄市鳥松區大埤路123號
電話: 07-731-7123 分機:2299
E-mail: zieben@cgmh.org.tw
研究領域:- 免疫
- 過敏學
- 皮膚學
- 毒物學
- 醫學之生化及分子生物
- 公共衛生及環境醫學
研究成果
This laboratory has been focusing on the molecular mechanisms of immune regulation in keloids, itch in atopic dermatitis (AD), and arsenic skin cancers. Incorporated with a comprehensive dermatology patient care in the medical center, an integrative live cell imaging ability, steady molecular and cell biology performance, this lab pursues the molecular mechanisms and the targeting therapeutic modalities in those diseases.
We found blood monocytes contribute to keloid pathogenesis by upregulating MCP-1 and AKT in fibroblasts, indicating a primary immunological defect in keloid pathogenesis (Exp Dermatol, 2010). Recently, we found that TGF-beta1 induces cell rigidity through smooth muscle actin in fibroblasts (J Dermatol Sci, 2012). Regarding to pathophysiology of itch, we found serum beta-endorphin level is associated with the subjective itch intensity in patients with AD (Brit J Dermatol, 2006). IL-31, a cytokine related to pruritus, activates IL-31R in keratinocytes, leading to calcium propagation, STAT3 activation, and finally release of beta-endorphin in AD (Brit J Dermatol, 2012). ORAI1, a calcium channel associated protein important in T cell activation, is found to have genetic polymorphism associated with AD (PLoS One, 2012). Cortical activation pattern is distinct for pain and itch as measured by near infrared spectroscope (NIRS) (PLoS One, 2013). In arsenic carcinogenesis, we reported that arsenic mobilizes epidermal Langerhans cells to regional lymph nodes and elicits a Th1 response (Biochem Pharmacol, 2012). In addition, we reported there is a synergistically apoptotic effect of arsenic and UVB in keratinocytes due to differential caspases activation (Chem Res Toxicol, 2004). Arsenic causes aberrant keratinocyte proliferation through mtTFA-mediated mitochondrial biogenesis (Am J Pathol, 2011). Further, mitochondria-derived oxidative stress and mitochondrial DNA damage are involved in the development of arsenic cancers (J Invest Dermatol, 2013).
工作經歷:
- 2017~迄今 長庚大學醫學系皮膚科教授
- 2014~2017 長庚大學醫學系皮膚科副教授
- 2014~迄今 高雄長庚醫院皮膚科主任
- 2013~迄今 高雄長庚醫院皮膚科副教授級主治醫師
- 2012~迄今 台灣研究皮膚科學會常務理事
- 2012~迄今 國際醫學地質學會台灣分會會員委員會主席
- 2012-2013 高雄醫學大學皮膚科部定副教授
- 2009-2012 高雄醫學大學皮膚科部定助理教授
- 2008-2013 高雄市立小港醫院皮膚科主任
- 2004-2006 美國NIH國家癌症中心客座學者
- 2003-2013 高雄醫學大學附設醫院主治醫師
學歷: - 高雄醫學大學醫學博士
- 高雄醫學院醫學士
殊榮:
- 2014 Selected oral presentation, Annual Meeting of Society of Investigative Dermatology, Albuquerque, NM.
- 2013 Invited Chair, Psoriasis 2013 Congress of Psoriasis International Network, Paris, France.
- 2013 Initial Meeting Abstract Reviewer, International Investigative Dermatology, Edinburgh, UK.
- 2012 Invited talk in Japanese Society of Investigative Dermatology, Okinawa, Japan.
- 2011 Invited talks in a course (Molecular biology, an introduction) and a workshop (Arsenic, an environmental thread), and invited as a chair in the free paper session (Molecular biology and wound healing) in Word Congress of Dermatology, Seoul, South Korea.
- 2011 Invited talk, Branch of Pulmonary and Critical Care, NHLBI, NIH, Bethesda, MD.
- 2010 Invited talk, 6th Conference of Metal Toxicity and Carcinogenesis, University of Kentucky, Lexington, KA.
- 2010 Selected oral presentation, Annual Meeting of Society of Investigative Dermatology, Atlanta, GA.
- 2008 Travel grant, Annual Meeting of International Investigative Dermatology, Kyoto, Japan.
- 2008 Travel grant, International Pigment Cell Conference, Hokkaido, Japan.
- 2007 Outstanding Grant Proposal Award, Taiwanese Dermatology Association, Taipei, Taiwan.
- 2004 Visiting fellow, NIH/NCI intramural trainee program, Bethesda, MD.
- 2003 Best Chief Resident, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
- 2002 Young Investigator’s Award, International Congress of Internal Medicine. Kyoto, Japan.
- 2001 Travel grant, Japanese Society of Investigative Dermatology, Ehime, Japan.
- 1997 Rank number three in National Medical Licensure Exam, Taipei.
- 1997 Rank number one in 1997 medical graduates, Kaohsiung Medical College, Kaohsiung.
- 1996 Outstanding scholar, Professor Ye's Pathology Award, Taipei.
代表論文:- Lee, C.H., Wu, S.B., Hong, C.H., Chen, G.S., Wei, Y.H., Yu, H.S. Involvement of mitochondrial DNA damage elicited by oxidative stress in the arsenical skin cancers. J Invest Dermatol, 2013, 133(7):1890-900.
- Lee, C.H., Hong, C.H., Yu, W.T., Chuang, H.Y., Huang, S.K., Chen, G.S., Yoshioka, T., Sakata, M., Liao, W.T., Ko, Y.C., Yu, H.S. Mechanistic correlations between two itch biomarkers, cytokine interleukin-31 and neuropeptide β-endorphin, via STAT3/calcium axis in atopic dermatitis. Br J Dermatol. 2012, 167(4):794-803.
- Lee, C.H., Hong, C.H., Yu, C.L., Wang, L.F., Clausen, B.E., Liao, W.T., Huang, S.K., Chen, G.S., Yu, H.S. Arsenic mobilizes Langerhans cell migration and induces Th1 response in epicutaneous protein sensitization via CCL21: a plausible cause of decreased Langerhans cells in arsenic-induced intraepithelial carcinoma. Biochem Pharmacol. 2012, 83(9):1290-9.
- Lee, C.H., Wu, S.B., Hong, C.H., Liao, W.T., Wu, C.Y., Chen G.S., Wei, Y.H., Yu, H.S. Aberrant cell proliferation by enhanced mitochondrial biogenesis through mtTFA in arsenical skin cancers. Am J Pathol. 2011, 178(5):2066-76.
- Lee, C. H., Kakinuma, T., Wang, J., Zhang, H., Palmer, D. C., Restifo, N. P. and Hwang, S. T., Sensitization of B16 tumor cells with a CXCR4 antagonist increases the efficacy of immunotherapy for established lung metastases. Mol Cancer Ther 2006. 5: 2592-2599.
所有論文著作一覽表
學會與認證:- 台灣皮膚科醫學會專科醫師
- 台灣皮膚科醫學會理事
- 台灣研究皮膚科學會常務理事
- 台灣教育部部定副教授
- 台灣醫學教育學會會員
- 美國研究皮膚科學會會員
- 國際醫學地質學會會員