何鴻耀, Ph.D.
現職: 長庚大學 生物技術暨檢驗學系
副教授
電話: 03-211-8800 分機: 3318
E-mail: hoh01@mail.cgu.edu.tw
研究領域:- 醫學之生化及分子生物
- 醫事技術及實驗診斷
- 免疫
研究成果
Redox environment can be the host factor affecting pathogenesis of degenerative and infection diseases. Oxidative stress enhances viral replication and cytopathic effects in virus-infected cells; the infection itself leads to increased oxidative stress. Additionally, the mechanism accounting for virus-induced oxidative stress is not completely clear. The main theme of my laboratory is to study how oxidative stress/damage is related to pathogenesis of degenerative diseases and viral infection, and how cellular metabolism changes during pathogenesis.
工作經歷:
2009-迄今 長庚大學 副教授
2003-2009 長庚大學 助理教授
2001-2002 紐約大學
博士後研究員
學歷:
1994-2000 國防醫學院生命科學研究所博士
1990-1992 成功大學生物化學研究所碩士
1986-1990 成功大學生物系學士
代表論文:
1. Cheng, M. L., Shiao, M. S., Chiu, D. T., Weng, S. F., Tang, H. Y., and Ho, H. Y. (2011). Biochemical disorders associated with antiproliferative effect of dehydroepiandrosterone in hepatoma cells as revealed by LC-based metabolomics. Biochem. Pharmacol. 82, 1549-1561.
2. Ho, H. Y., Cheng, M. L., Shiao, M. S., Chiu, D. T. Y. (2013). Characterization of global metabolic responses of glucose-6-phosphate dehydrogenase-deficient hepatoma cells to diamide-induced oxidative stress. Free Radic. Biol. Med. 54, 71-84.
3. Cheng, M. L., Ho, H. Y.*, Lin, H. Y., Lai ,Y. C., Chiu, D. T. Y. (2013). Effective NET formation in neutrophils from individuals with G6PD Taiwan-Hakka is associated with enhanced NADP+ biosynthesis. Free Radic. Res. 47, 699-709.
4. Ho, H.Y., Cheng, M. L., Chiu D. T. Y. (2014).Glucose-6-phosphate dehydrogenase-beyond the realm of red cell biology. Free Radic. Res. 48, 1028-1048.
5. Cheng, M. L., Weng, S. F., Kuo, C. H., Ho, H. Y. (2014). Enterovirus 71 induces mitochondrial reactive oxygen species generation that is required for efficient replication. PLoS One. 9, e113234.
*Co-first author
# Co-corresponding author