林錫賢 , Ph.D
單位: 長庚大學
現職: 微生物及免疫學科 教授
電話: 03-2118800 分機: 3321 傳真: 03-211846
E-mail: hhlin@mail.cgu.edu.tw
研究領域:- 免疫
- 醫學之生化及分子生物
研究成果:
1. I have generated F4/80 knock-out mice to characterize the biological functions of the molecule in vivo.
2. I am actively involved in identification of new members of the adhesion-GPCR family and the elucidation of the functions of these receptors including their specific expression patterns and the identification of their cellular ligands, etc.
3. Another area of interest in the post-translational modification of the adhesion-GPCR receptor, which involves a conserved proteolytic cleavage process and its functional role.
工作經歷:2011/8–present Professor/Laboratory Head, Laboratory of Molecular Immunology, Department of Microbiology and Immunology, Chang Gung University, Taiwan.
2007/8–2011/7 Associate Professor/Laboratory Head, Laboratory of Molecular Immunology, Department of Microbiology and Immunology, Chang Gung University, Taiwan.
2004/12–2007/7 Assistant Professor/Laboratory Head, Laboratory of Molecular Immunology, Department of Microbiology and Immunology, Chang Gung University, Taiwan.
2000/7–2004/11 Group leader/Senior Research Fellow, Sir William Dunn School of Pathology, the University of Oxford, UK.
學歷:1992/8 – 1997/12 Ph.D., Oak Ridge Graduate School of Biomedical Sciences, University of Tennessee – Knoxville, TN, U.S.A.
殊榮:- 1992-1997 UT-Oak Ridge Graduate School of Biomedical Sciences, Pre-doctoral Fellowships
- 1997 University of Tennessee - Knoxville
Chancellor’s Citation for Extraordinary Professional Promise
(The highest honor for a graduate student in the University) - 1998-2000 Wellcome Trust Cardiovascular Research Initiative Research Fellowship, U.K.
- 2000-2002 Celltech Ltd. Senior Research Fellowship, U.K.
- 2002-2004 British Heart Foundation Research Fellowship, UK
- 長庚大學99-101年度國科會補助大專校院獎勵特殊優秀人才獎
- 2012-Present Board Member, Adhesion-GPCR Consortium
代表論文: 1. N.-Y. Chiang, C.-C. Hsiao, Y.-S. Huang, H.-Y. Chen, I-J. Hsieh, G.-W. Chang, H.-H. Lin* 2011 Disease-associated GPR56 mutations cause bilateral frontoparietal polymicrogyria via multiple mechanisms.J. Biol. Chem. 286(16): 14215-14225.
2. Y.-M. Peng, Martijn D.B. van de Garde, K.-F. Cheng, P.A. Baars, R.A.W. van Lier, C.R. Mackay, H.-H. Lin*, and J. Hamann* 2011 Specific expression of GPR56 by human cytotoxic lymphocytes. J. Leukoc. Biol. 90:735-740
3. Y.-S. Huang, N.-Y. Chiang, C.-H. Hu, C.-C. Hsiao, K.-F. Cheng, W.-P. Tsai, Simon Yona, Martin Stacey, Siamon Gordon, G.-W. Chang* and H.-H. Lin* 2012 Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and interaction of receptor subunits in lipid raft microdomains. Mol. Cell. Biol. 32(8): 1408-1420
4. W.-Y. Tseng, Y.-S. Huang, N.-Y. Chiang, Y.-P. Chou, Y.-J. Jan Wu, S.-F. Luo, C.-F. Kuo, K.-M. Lin, andH.-H. Lin* 2013 Increased soluble CD4 in serum of rheumatoid arthritis patients is generated by matrix metalloproteinase (MMP)-like proteinases. PLoS ONE 8(5): e63963.
5. C.-C. Hsiao&, W.-C. Wang&, W.-L. Kuo, H.-Y. Chen, T.-C. Chen, J. Hamann, H.-H. Lin* 2014 CD97 inhibits cell migration in human fibrosarcoma cells by modulating TIMP-2/MT1-MMP/MMP-2 activity. FEBS Journal 281(21):4878-91.
所有論文著作一覽表