專業人才

傅崇安 ,Ph.D.
單位: 長庚大學
現職: 生物醫學系教授
聯絡地址: 333桃園市龜山區文化一路259號
電話: 03-2118800 分機:3478
E-mail: sdfugmann@mail.cgu.edu.tw

研究領域:
  • 免疫
  • 醫學之生化及分子生物
研究成果
All multicellular organisms are constantly challenged by a plethora of potentially lethal
pathogens and thus require protection to survive. These defense mechanisms can be
broadly divided into the "innate" and the "adaptive" immune systems. The former relies
on the recognition of conserved pathogen associated molecular patterns where as the
latter utilizes randomly generated antigen receptors, immunoglobulins (Igs) and T cell
receptors (TCRs), without pre-defined specificities. The central theme of my laboratory is
to understand the molecular mechanisms of programmed gene rearrangements and
mutagenesis that generate the diverse antigen receptor repertoires essential for adaptive
immunity.

工作經歷:
2004-2013 研究員, National Institute on Aging / NIH, Baltimore, Maryland, USA
2013- 迄今 教授, 長庚大學生物醫學系

學歷:
1990 Vordiplom (學士), 化學, University of Hamburg, Germany
1993 Diplom (碩士), 物理化學, University of Constance, Germany
1998 博士., 人體生物學, University of Ulm, Germany
1998-2004 博士後研究, Yale University, New Haven

殊榮:
1994 Predoctoral Fellowship, Deutsche Forschungsgemeinschaft (DFG), Graduiertenkolleg fuer Biomolekulare Medizin, University of Ulm, Germany
2001 Postdoctoral Fellowship, Irvington Institute for Immunological Research, USA

代表論文:
  1. Fugmann, S.D., Villey, I.J., Ptaszek, L.M., and D.G. Schatz, D.G. Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex.  Mol. Cell 5: 97-107, 2000.
  2. Fugmann, S.D., Messier, C., Novack, L.A., Cameron, R.A., and Rast, J.P.: An ancient evolutionary origin of the RAG1/2 gene locus.  Proc. Natl Acad. Sci. USA 103: 3728-3733, 2005.
  3. Sea Urchin Genome Sequencing Consortium (including Fugmann, S.D.): The genome of the sea urchin Strongylocentrotus purpuratus.  Science 314: 941-952, 2006.
  4. Kothapalli, N., Norton, D.D., and Fugmann, S.D.: Cutting Edge: A cis-acting DNA element targets AID-mediated sequence diversification to the chicken Ig light chain gene locus.  J. Immunol. 180: 2019-2023, 2008.  
  5. Kothapalli, N.K., Fugmanns, S.D.: Targeting of AID-mediated sequence diversification to immunoglobulin genes. Curr. Opin. Immunol. 23: 184-189, 2011.  PMCID: PMC3073656

所有論文著作一覽表


目前進行中研究計畫:
2013/3/1 – 2016/2/28 從一個在適應性免疫系統生成起始點上的長壽無脊椎動物對免疫系統的探索
2013/8/1 – 2016/7/31 由突變加強因子主導之免疫球蛋白基因序列變異