Expertise at Chang Gung System

Leu, Yann-Lii ,Ph.D.
Institution: Chang Gung University
Position: Associate professor
Department: Graduate Institute of Natural Products
Address: 259 Wen-Hwa 1st Road, Kwei-Shan Tao-Yuan,Taiwan,33302
Tel: +886-3-2118800ext3719

Focus of Interest:
  • Oncology
  • Biochemistry and Molecular Biology - Medicine
  • Pharmacology & Pharmacy
Fulltime Employment:
  • 2012/08- present Assistant Professor Graduate Institute of Natural Products, Chang Gung University
  • 2010/09- 2012/07 Postdoctoral Fellow Department of Biochemistry and Molecular Biology, MD Anderson Cancer Center

  • 2005/09- 2010/08 Ph.D. Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center
  • 1998/09- 2000/08 M.S. Institute of Molecular Medicine, National Cheng Kung University

Selected Main Publications:
  1. Hu Z, Chen K, Xia Z, Chavez M, Pal S, Seol JH, Chen CC, Li W, Tyler JK. Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging. (2014) Genes & Development, 15;28(4):396-408
  2. Chen, C-C. & Tyler, J. K. Selective sensitization of cancer cells to DNA damage by a HAT inhibitor. (2009) Cell Cycle 8(18).
  3. Chen, C-C. & Tyler, J. K. Chromatin assembly signals the end of repair. (2008) Cell Cycle, 7, 3792-7.
  4. Chen, C-C., Carson, J., Feser, J., Tamburini, B., Zabaronick, S., Linger, J. & Tyler, J. K. Acetylation of lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of double-strand DNA repair. (2008) Cell, 134, 231-43.
  5. Zhang Z, Yang K, Chen CC, Feser J, Huang M. Role of the C terminus of the ribonucleotide reductase large subunit in enzyme regeneration and its inhibition by Sml1. (2007) Proc Natl Acad Sci, 104(7): 2217-2222

All Publications List