Expertise at Chang Gung System

Jou, Mei-Jie ,Ph.D.
Institution: Chang Gung University
Position: Associate professor
Department: Department of Physiology and Pharmacology
Address: No.259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 333, Taiwan (R.O.C.)
Tel: +886-3-2118800 ext. 5974 (Lab); 5251 (office)
E-mail: mjjou@mail.cgu.edu.tw

Focus of Interest:
  • Pharmacology and Toxicology
  • Physiology
  • Laser scanning multi-photon microscopy
  • Pathophysiology of mitochondria-mediated apoptosis
  • Neurodegenerative diseases (Parkinson's disease and Alzheimer's disease)
  • Nano-medicine, phototoxicity and photodynamic therapy
  • Mitochondrial diseases

Fulltime Employment:
  • 2006- Associate Professor Division of Physiology and Pharmacology Chang Gung University, Taoyuan, Taiwan
  • 1999 - 2006 Assistant Professor Division of Physiology and Pharmacology Chang Gung University, Taoyuan, Taiwan

Education:
  • 1987/ 09 - 1992/06 Ph.D. Department of Pharmacology University of Rochester, USA
  • 1984/ 09 - 1986/06 Master College of Medicine National Taiwan University, Taiwan
  • 1978/ 09 - 1982/06 Bachelor School of Pharmacy Kaohsiung Medical University, Taiwan

Honors and Awards:
  • 2009: The Foundation of Taiwan Medical Development Awards for Outstanding Writings in 2009 Cheng-En Hsieh (Adviser: Prof. Mei-Jie Jou)
  • 2008: The Foundation of Taiwan Medical Development Awards for Outstanding Writings in 2008 Cheng-En Hsieh (Adviser: Prof. Mei-Jie Jou)
  • 2007: 2007 Edition of Who’s Who in the World, USA
  • 2006: The American Hall of Fame by American Biographical Institute, INC., USA
  • 2006: International Travel Grant at Biophysical Society, USA
  • 2005: Young Investigator Award by First Annual Meeting of The American Academy of Nanomedicine (AAAM), USA
  • 2005: Leading Scientists of the World in The Area of Mitochondria Research by International Biographical Center Headquarters in Cambridge, England
  • 2005: American Academy of Nanomedicine invited as a founder member
  • 2004: The Korean Society for Free Radical Research as a key note lecture speaker
  • 2004: International Travel Grant by Biophysical Society, USA

Selected Main Publications:
  1. Hsiao CW, Peng TI, Peng AC., Reiter RJ, Tanaka M, Lai YK and Jou MJ*. Long-term Aβ exposure augments mCa2+-independent mROS-mediated depletion of cardiolipin for the shift of a lethal transient mitochondrial permeability transition to its permanent mode in NARP cybrids: a protective targeting of melatonin. J. Pineal Res. 2013, 54:107-125.
  2. Peng TI, Hsiao CW, Reiter RJ, Tanaka M, Lai YK and Jou MJ*. mtDNA T8993G mutation-induced mitochondrial complex V inhibition augments cardiolipin-dependent alterations in mitochondrial dynamics during oxidative, Ca2+ and lipid insults in NARP cybrids: a potential therapeutic target for melatonin. J. Pineal Res. 2012, 52(1):93-106.
  3. Jou MJ*. Pathophysiological and pharmacological implications of mitochondria-targeted reactive oxygen species generation in astrocytes. Adv. Drug Deliv. Rev. 2008, 60(13-14):1512-1526.
  4. Jou MJ*, Peng TI, Yu PZ, Jou SB, Reiter RJ, Chen JY, Wu HY and Hsu LF.  Melatonin protects against common deletion of mitochondrial DNA-augmented mitochondrial oxidative stress and apoptosis. J. Pineal Res. 2007, 43(4):389-403.
  5. Jou MJ*, Peng TI, Reiter RJ, Jou SB, Wu HY, and Wen ST. Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress-induced apoptosis of rat brain astrocytes. J. Pineal Res. 2004, 37(1):55-70.


All Publications List

Board Certification:

    Reviewer for Seicntific Journals:

  • Journal of Molecular Histology (USA)
  • Life Science (USA)
  • Acta Pharmacological (China)
  • Molecular Brain Research (USA)
  • Society for Free Radical Biology and Medicine (USA)
  • Journal of Pineal Research (USA)
  • FEBS letter (Federation of European Biochemical Societies)
  • Review Editor of Frontiers in Genetics of Aging. (invited by Professor Henry Markram, president of Frontiers Research Foundation)
  • The Natural Products Journal (invited by Prof. Atta-ur-Rahman, FRS, chief editor of Natural Products Journal )
  • Journal of Biochemical and Pharmacological Research (invited by Prof. Liang -Jun Yan, chief editor of Journal of Biochemical and Pharmacological Research )
  • Review Editor of Frontiers in Genetics of Aging (invited by Professor Elena G. Pasyukova, Guest Associate Editor, Frontiers in Genetics of Aging)
  • PLOS ONE
  • BBA (Biochimica et Biophysica Acta)

    • Memberships:

  • Biophysical Society, USA
  • Free Radical Biology and Medicine, USA
  • Mitochondria Research Society, USA
  • Nanomedicine, USA
  • Oxygen Club of California, USA (on the advisory board)
  • AAAS and Science, USA