Jung-Tung Hung ,Ph.D.
Division: Institute of Stem Cell and Translational Cancer Research
Position:
Assistant Research Fellow
Office Address: Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, No. 5, Fu-Sing St., Kuei Shang, Taoyuan 333, Taiwan
Tel: +886-3-328-1200, ext. 8067
E-mail: felixhjt@gmail.com
Focus of Interest:- Molecular mechanisms of tumor associated carbohydrate antigen during tumorigenesis.
- Carbohydrate-based cancer vaccine development.
- Immunotherapeutic effects of iNKT cells on hepatocellular carcinoma.
Employment Records: 2006/1 ~ 2013/5 Postdoctoral fellows, Genomics research center, Academia Sinica
Education: 1993/9 ~ 1997/7 BS, Department of Medical Sciences and Technology, Chung-Shan Medical University
1997/9 ~ 1999/7 MS, Institute of Microbiology and Immunology, National Defense Medical Center
1999/9 ~ 2005/10 Ph.D, Institute of Life Sciences, National Defense Medical Center
Honor and Awards: - 2007 Academia Sinica Regular Postdoctoral Fellow
- 2009 Travel scholarship for 5th International Symposium on CD1/NKT Cells
- 2009 Academia Sinica Regular Postdoctoral Fellow
- 2010 Outstanding Post-Doctor Researchers Conference Travel Grant from Foundation for the Advancement of Outstanding Scholarship
Patent:1. Alpha-galactosyl ceramide analogs and their use as immunotherapies. Application number: 12/218,082. Publication number: US 2010/0008954 A1. Filing date: 11 Jul 2008. Issued patent: US7928077 (Issue date 19 Apr 2011)
2. Alpha-galactosyl ceramide analogs and their use as immunotherapies, adjuvants, and antibiral, antibacterial, and anticancer. Publication number, EP2320947 A2. Filing date, Jul 10, 2009.
Selected Publications:1.Sytwu, H. K., Lin, W. D., Roffler, S. R., Hung, J. T., Sung, H. S., Wang, C. H., Cheng, T. L., Tsou, S. C., Hsi, S. C. & Shen, K. L. (2003) Anti-4-1BB-based immunotherapy for autoimmune diabetes: lessons from a transgenic non-obese diabetic (NOD) model, J Autoimmun, 21, 247-54.
2. Sung, H. H., Juang, J. H., Lin, Y. C., Kuo, C. H., Hung, J. T., Chen, A., Chang, D. M., Chang, S. Y., Hsieh, S. L. & Sytwu, H. K. (2004) Transgenic expression of decoy receptor 3 protects islets from spontaneous and chemical-induced autoimmune destruction in nonobese diabetic mice, J Exp Med, 199, 1143-51.
3. Hung, J. T., Liao, J. H., Lin, Y. C., Chang, H. Y., Wu, S. F., Chang, T. H., Kung, J. T., Hsieh, S. L., Mcdevitt, H. & Sytwu, H. K. (2005) Immunopathogenic role of TH1 cells in autoimmune diabetes: evidence from a T1 and T2 doubly transgenic non-obese diabetic mouse model, J Autoimmun, 25, 181-92.
4. Chang, Y. J., Huang, J. R., Tsai, Y. C., Hung, J.T., Wu, D., Fujio, M., Wong, C. H. & Yu, A. L. (2007) Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids, Proc Natl Acad Sci U S A, 104, 10299-304.
5. Chang, W. W., Lee, C. H., Lee, P., Lin, J., Hsu, C. W., Hung, J.T., Lin, J. J., Yu, J. C., Shao, L. E., Yu, J., Wong, C. H. & Yu, A. L. (2008) Expression of Globo H and SSEA3 in breast cancer stem cells and the involvement of fucosyl transferases 1 and 2 in Globo H synthesis, Proc Natl Acad Sci U S A, 105, 11667-72.
6. Wang, C. C., Huang, Y. L., Ren, C. T., Lin, C. W., Hung, J.T., Yu, J. C., Yu, A. L., Wu, C. Y. & Wong, C. H. (2008) Glycan microarray of Globo H and related structures for quantitative analysis of breast cancer, Proc Natl Acad Sci U S A, 105, 11661-6.
7. Lai, C. Y., Hung, J.T., Lin, H. H., Yu, A. L., Chen, S. H., Tsai, Y. C., Shao, L. E., Yang, W. B. & Yu, J. (2010) Immunomodulatory and adjuvant activities of a polysaccharide extract of Ganoderma lucidum in vivo and in vitro, Vaccine, 28, 4945-54.
8.*Hsieh, M. H., *Hung, J.T., Liw, Y. W., Lu, Y. J., Wong, C. H., Yu, A. L. & Liang, P. H. (2012) Synthesis and evaluation of acyl-chain- and galactose-6''-modified analogues of alpha-GalCer for NKT cell activation, Chembiochem, 13, 1689-97.
9.*Huang, Y. L., *Hung, J.T., *Cheung, S. K., Lee, H. Y., Chu, K. C., Li, S. T., Lin, Y. C., Ren, C. T., Cheng, T. J., Hsu, T. L., Yu, A. L., Wu, C. Y. & Wong, C. H. (2013) Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer, Proc Natl Acad Sci U S A, 110, 2517-22.
10.Tsai Y. C., Huang J. R., Cheng J. Y., Lin J. J., Hung J. T., Wu Y. Y., Yeh K. T. and Yu A. L. (2013) A Prevalent Cancer Associated Glycan, Globo H Ceramide, Induces Immunosuppression by Reducing Notch1 Signaling. J Cancer Sci Ther, 5(7), 264-270
* co-first author
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