Hung-Li Wang , Ph.D.
Institution: Chang Gung University
Position: Professor
Department: 1. Department of Physiology and Pharmacology, College of Medicine, Chang Gung University
2. Neuroscience Research Center, Chang Gung Memorial Hospital
Address: No. 259, Wen-Hwa 1 Rd, Gueishan Township, Taoyuan County 333,
Taiwan (R.O.C.)
Tel: 886-3-2118800, Ext.5060. Fax: 886-3-2118700 
E-mail: hlwns@mail.cgu.edu.tw
Focus of Interest:- Neurosciences
Fulltime Employment: ◎ 1992-2001 Associate Professor, Department of Physiology, College of Medicine, Chang Gung University
◎ 2001-2008 Professor, Department of Physiology and Pharmacology, College of Medicine, Chang Gung University
◎ 2002-2009 Assistant Professor, Department of Medical Imaging and Radiological Sciences, ChangGung University
◎ 2008- Professor and Chairman, Department of Physiology and Pharmacology, College of Medicine, Chang Gung University
Education: 》National Taiwan University, B.S. 06/1983 Pharmacy
》National Taiwan University, M.S. 06/1985 Pharmacology
》University of Pennsylvania Ph.D. 04/1990 Pharmacology
Selected Main Publications:- Chou JS, Chen CY, Chen YL, WengYH, Yeh TH, Lu CS, Chang YM, Wang HL* (2014) (G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse. Neurobiology of Disease, 68, 190-199.
- Chen CY, Weng YH, Chien KY, Lin KJ, YehTH, Cheng YP, Lu CS, Wang HL* (2012) (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD. Cell Death & Differentiation, 19, 1623-1633.
- Chou AH, Yeh TH, Ouyang P, Chen YL, Chen SY and Wang HL*(2008) Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation. Neurobiology of Disease, 31, 89-101.
- Chou AH, Yeh TH, Kuo YL, Kao YC, Jou MJ, Hsu CY, Tsai SR, Kakizuka A and Wang HL* (2006) Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-xL. Neurobiology of Disease, 21, 333-345.
- Yeh TH, Hwang HM, Chen JJ, Wu T, Li A and Wang HL* (2005) Glutamate transporter function of rat hippocampal astrocytes is impaired following the global ischemia. Neurobiology of Disease, 18, 476-483.
Full Publication List
Board Certification:1. Member of the Chinese Physiological Society
2. Member of the Pharmacological Society in Taiwan
3. Member of Society for Neuroscience USA
Ongoing projects：1. Investigating molecular pathogenic mechanisms of mutant CUL4B-induced X-linked mental retardation (2014/8-2015/7).
2. An investigation on molecular pathogenic mechanisms of mutant PTEN-induced autism spectrum disorder (2014/7-2015/6).
3. Investigating cellular and molecular pathogenic mechanisms underlying mutant LRRK2-induced neurotoxicity of nigrostriatal system and physiological functions of LRRK2 in the brain using mutant LRRK2 knockin mice and LRRK2 knockout mice (2014/10-2015/9).