Expertise at Chang Gung System

Chang, Kuo-Hsuan , M.D.,Ph.D.
Institution:Center/Chang Gung University
Position:Director/Assistant professor/ Physician scientist
Department: Department of Neurology (Chang Gung Memorial Hospital-Linkou Medical Center)/School of Medicine (Chang Gung University)
Address: No.5, Fusing St., Gueishan Township, Taoyuan County 333, Taiwan (R.O.C.)
Tel: +886-3-3281200
Fax: +886-3-3288849
E-mail: gophy5128@cgmh.org.tw

Focus of Interest:
  • Stem cell
  • Immunology
  • Neurosciences

Employment Record:
Assistant professor, School of Medicine, Chang Gung University

Education:
M.D., School of Medicine, Taipei Medical College
Ph.D., Clinical Science Centre, Imperial College London U.K.

Honors and Awards:
Best intern

Selected Publications:

  1. Chang KH, Li M (2013). Clonal Isolation of an Intermediate Pluripotent State.Stem Cells 31: 918-927 (SCI) corresponding author
  2. Chang KH, Chen CM, Chen YC, Lyu RK, Chang HS, Ro LS, Lee-Chen GJ, Wu YR (2013). Association between PARK16 and Parkinson’s disease in the Han-Chinese population: a meta-analysis. Neurobiology of Aging 34(10):2442.e5-9
  3. Chang KH, Chen WL, Wu YR, Lin TH, Wu YC, Chao CY, Lin JY, Lee LC, Chen YC, Lee-Chen GJ, Chen CM. Aqueous extract of Gardenia jasminoides targeting oxidative stress to reduce polyQ aggregation in cell models of spinocerebellar ataxia 3. (2014). Neuropharmacology 81:166-175
  4. Chang KH, Lyu RK, Chen CM, Wu YR, Chang HS, Huang CC, Kuo HC, Chu CC, Hsu WC, Ro LS (2013). Distinct features between longitudinally extensive transverse myelitis presenting with and without anti-Aquaporin 4 antibodies. Multiple Sclerosis Journal 19: 299-307
  5. Chang KH, Chen CM, Chen YC, Hsiao YC, Huang CC, Kuo HC, Hsu HC, Lee-Chen GJ, Wu YR (2013). Association between GRN rs5848 polymorphism and Parkinson’s disease in Taiwanese population. PLoS One 8(1):e54448 (SCI).

All Publications

Board Certification：
Board-certified Neurologist

Ongoing projects：
(1) Exploring novel therapeutic strategies targeting amyloid-β and tau aggregation for Alzheimer's disease by cell models (NSC102-2321-B-182-013-) 2013/8/1-2015/7/31 National Science Council (PI)
(2) Establishment of neurodegenerative disease-specific induced pluripotent stem cell lines (CMRPG 3A0691-93). 2011/6/1~2014/10/30 Chang Gung Memorial Hospital (PI)
(3) Investigating immunopathogenesis and biomarkers of chronic immune-mediated neuropathies (CMRPG3C1631) 2013/10/1~2016/9/30 Chang Gung Memorial Hospital (PI)