Expertise at Chang Gung System

Chen Chiung-Mei , M.D.,Ph.D.
Institution: Linkou chang gung memorial hospital
Position:Professor/Physician/ Physician Scientists
Department: Department of Neurology
Address: No.5, Fusing St., Gueishan Township, Taoyuan County 333, Taiwan (R.O.C.)
Tel:(03) 3281200 EXT: 8340
E-mail: cmchen@adm.cgmh.org.tw

Focus of Interest:
  • Parkinson’s disease
  • Spinocerebellar Atrophy
  • Huntington’s Disease
  • movement disorders
  • neurogenetic disorders

Employment Record:
Present, Professor, Department of Neurology, Chang Gung Memorial Hospital

Education:
Sep 1980-June 1987 M.D., Taipei Medical College, Taipei, Taipei Medical College
Post-Graduate Education:
Oct 1998-Aug 2002 Ph.D., Division of Molecular Genetics, Institute of Biochemistry and life Sciences, University of Glasgow, U.K.

Selected Publications:

  1. Chen CM, Liu JL, Wu YR, Chen YC, Cheng HS, Cheng ML, Chiu D TY*. Increased oxidative damage in peripheral blood correlates with severity of Parkinson's disease. Neurobiol Dis. 2009; Mar,33:429–435 (SCI；IF＝4.852；Neuroscience 38/219)。
  2. Sidransky E, Nalls MA, Aasly JO, Aharon-Peretz J, Annesi G, Barbosa ER, Bar-Shira A, Berg D, Bras J, Brice A, Chen CM, et al. Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson Disease. New England Journal of Medicine. 2009;361:1651-1661. Medicine. 2009;361:1651-1661
  3. Lin YS, Chen CM, Soong BW, Wu YR, Chen HM, Yeh WY, Wu DR, Lin YJ, Poon PW, Cheng ML, Wang CH, Chern Y. Dysregulated brain creatine kinase is associated with hearing impairment in mouse models of Huntington disease. J Clin Invest. 2011 Apr 1;121(4):1519-23. (Co-first author) (14.15)
  4. Chang KH, Chen WL, Wu YR, Lin TH, Wu YC, Chao CY, Lin JY, Lee LC, Chen YC, Lee-Chen GJ, Chen CM*. Aqueous extract of Gardenia jasminoides targeting oxidative stress to reduce polyQ aggregation in cell models of spinocerebellar ataxia 3. Neuropharmacology. 2014 Jun;81:166-75.
  5. Chen CM, Weng YT, Chen WL, et al. Aqueous extract of Glycyrrhiza inflata inhibits aggregation through upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3. Free Radic Biol Med. 2014  Mar 25;71C:339-350.

All Publications

Board Certification：
Taiwan neurological association

Ongoing projects：
1. 探討神經發炎及抗醣抗體在漢丁頓病人及轉殖鼠所扮演的角色以找出疾病生物指標及治療策略
2. 運用漢丁頓病人血液及多能性幹細胞探討神經發炎、氧化壓力及代謝路徑相關的生物指標及治療策略(1/3)
3. 視聽障礙在漢丁頓舞蹈症的病程發展-兩年的追蹤計畫
4. 運用細胞及動物模型探討增強PARK15(FBXO7)表現作為巴金森氏症治療策略(1/3)