Expertise at Chang Gung System

Pai, Li-Mei ,Ph.D.
Institution: Chang Gung University
Position: Associate Professor
Department: Graduate Institute of Biomedical Sciences, Department of Biochemistry
Address: 259 Wen-Hwa 1st Road, Kwei-Shan Tao-Yuan, Taiwan, 333
Tel: 886-3-2118800 EXT 5520 Fax: 886-3-2118065
E-mail: pai@mail.cgu.edu.tw

Focus of Interest:
  • EGFR signal transduction
  • Endocytosis
  • Drosophila development
  • Methionine and pyrimidine metabolism
  • Regeneration
  • Stem cells
  • Nutrition and fertility

Fulltime Employment:
  • Chang Gung University, Department of Biochemistry Assistant Professor (2001-2010) Associated Professor (2010-Present)
  • HHMI, Princeton University, Department of Molecular Biology Postdoctoral Fellow (1997/9-2000/12)
  • Advisor: Dr. Trudi Schüpbach Academia Sinica, Institute of Biomedicine Research assistant : 1989-1991

Education:
  • Department of Biology, University of North Carolina at Chapel Hill 1992-1997 Advisor: Dr. Mark Peifer Ph. D. Dissertation: “Analysis of the functions of Drosophila Armadillo in Wingless signal transduction and at adherens junctions”
  • Department of Microbiology and Immunology, National Yang-Ming University, Taiwan 1987-1989 Advisor: Dr. Tze-Kun Ho Master thesis:”Analysis of the functions of Latent Membrane Protein of Epstein-Barr Virus by transfection of LMP into Trophoblast-like cells.”
  • Department of Microbiology Soochow University, Taiwan B.S.1984-1987

Selected Main Publications:
  1. Yi-Cheng Tsai, Wei Chiang, Willisa Liou, Wei-Hao Lee, Yu-Wei Chang, Yi-Chen Li, Pei-Yu Wang, Tsubasa Tanaka, Akira Nakamura, and Li-Mei Pai*. (2014, 2) Endophilin B is required for Drosophila oocyte to endocytose yolk downstream of Oskar. Development. 141 (3):563-573. SCI
  2. Pei-Yu Wang and Li-Mei Pai*. (2011.02) D-Cbl binding to Drk leads to dose-dependent down-regulation of EGFR signaling and increases receptor-ligand endocytosis. PLoSONE. 6(2) e17097. SCI
  3. Chang, W. L., Liou, W., Pen, H.C., Chou, H.Y., Chang, Y.W., Li, W.-H., Chiang, W. and Li-Mei Pai*. (2008) The gradient of Gurken, a long range morphogen, is directly regulated by Cbl-mediated endocytosis. Development, 135, 1923-1933.
  4. Pai, L.-M. Barcelo, G. and Schüpbach, T. (2000) D-cbl, a negative regulator of the Egfr pathway, is required for dorsoventral patterning in Drosophila oogenesis. Cell. 103, 51-61.
  5. Li-Mei Pai, Orsulic, S., Bejsovec, A., and Peifer, M. (1997) Negative regulation of Armadillo, a Wingless effector in Drosophila. Development. 124, 2255-2266.


All Publications List

Board Certification :

  • Member of American Society of Genetics
  • Member of American Society of Cell Biology
  • Member of Taiwan Society of Developmental Biology