Cheng-Lung Ku , Ph.D.
Intitution: Chang Gung University
Position: Assistant Professor
Department: Graduate Institute of Clinical Medical Sciences 
Tel: +886-3-211-8800 ext.3483
E-mail: CLKU@mail.cgu.edu.tw
Focus of Interest:- Human Immunology
- Infectious disease
- Autoantibodies
- Novel Primary Immunodeficiency
- Adult Onset Immunodeficiency (Autoantibodes to IFN-gamma)
1. Host factors of severe mycobacterial and pyogenic bacterial infection.
2. Molecular Mechanism of Anti-IFN-gamma Autoantibodies Disease in Patients with Non- tuberculous Mycobacterial Infection.
3. Role of Innate Immunity Against Enterovirus infection in human.
Employment Records:2008-2010: Assistant professor Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
2010-Present: Assistant professor Graduate Institute of Clinical Medical Science, Chang-Gung University, Taoyuan, Taiwan
2011-Present: Adjunct assistant professor Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
Education:2001-2007 PhD, Immunology Université Paris V René Descartes, INSERM U550 Paris, France.
1998-2000 Master Degree Institute of Microbiology and Immunology, Faculty of life science, National Yang-Ming University, Taipei, Taiwan
Honor and Awards:- 2001 Ph.D fellowship from the French ministry of foreign affairs (2001)
- 2013 Keystone Symposia Global Health Travel Award, funding by Bill & Melinda Gates Foundation.
Selected Publications:(*: first, co-first or corresponding author) 1. Chi CY, Chu CC, Liu JP, Lin CH, Ho MW, Lo WJ, Lin PC, Chen HJ, Chou CH, Feng JY, Fung CP, Sher YP, Li CY, Wang JH & Ku CL*. Anti-IFN-gamma autoantibodies in adults with disseminated nontuberculous mycobacterial infections are associated with HLA-DRB1*16:02 and HLA-DQB1*05:02 and the reactivation of latent varicella-zoster virus infection. Blood. 2013, 121: 1357-1366.
2. von Bernuth H, Picard C, Jin Z, Pankla R, Xiao H, Ku CL, Chrabieh M, Mustapha IB, Ghandil P, Camcioglu Y, Vasconcelos J, Sirvent N, Guedes M, Vitor AB, Herrero-Mata MJ, Arostegui JI, Rodrigo C, Alsina L, Ruiz-Ortiz E, Juan M, Fortuny C, Yague J, Anton J, Pascal M, Chang HH, Janniere L, Rose Y, Garty BZ, Chapel H, Issekutz A, Marodi L, Rodriguez-Gallego C, Banchereau J, Abel L, Li X, Chaussabel D, Puel A & Casanova JL. Pyogenic bacterial infections in humans with MyD88 deficiency. Science. 2008, 321: 691-696.
3. Ku CL, von Bernuth H, Picard C, Zhang SY, Chang HH, Yang K, Chrabieh M, Issekutz AC, Cunningham CK, Gallin J, Holland SM, Roifman C, Ehl S, Smart J, Tang M, Barrat FJ, Levy O, McDonald D, Day-Good NK, Miller R, Takada H, Hara T, Al-Hajjar S, Al-Ghonaium A, Speert D, Sanlaville D, Li X, Geissmann F, Vivier E, Marodi L, Garty BZ, Chapel H, Rodriguez-Gallego C, Bossuyt X, Abel L, Puel A & Casanova JL. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J. Exp. Med. 2007, 204: 2407-2422.
4. Ku CL*, Yang K, Bustamante J, Puel A, von Bernuth H, Santos OF, Lawrence T, Chang HH, Al-Mousa H, Picard C & Casanova JL. Inherited disorders of human Toll-like receptor signaling: immunological implications. Immunol. Rev. 2005, 203: 10-20.
5. Picard C, Puel A, Bonnet M, Ku CL, Bustamante J, Yang K, Soudais C, Dupuis S, Feinberg J, Fieschi C, Elbim C, Hitchcock R, Lammas D, Davies G, Al-Ghonaium A, Al-Rayes H, Al-Jumaah S, Al-Hajjar S, Al-Mohsen IZ, Frayha HH, Rucker R, Hawn TR, Aderem A, Tufenkeji H, Haraguchi S, Day NK, Good RA, Gougerot-Pocidalo MA, Ozinsky A & Casanova JL. Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science. 2003, 299: 2076-2079.
Research Resources:Mouse strains: none
Cell lines: 293T, EBVB, Human Skin Fibroblast, B95.8, S2
Special technology: none