Expertise at Chang Gung System

Hsi-Hsien Lin , Ph.D.
Intitution: Chang Gung University
Position:  Associate Professor
Department: Microbiology and Immunology
Laboratory of Molecular Immunology
Tel: 886-(0)3-2118800 ext: 3321 Fax: 886-(0)3-211846
E-mail: hhlin@mail.cgu.edu.tw

Focus of Interest:
1.I have generated F4/80 knock-out mice to characterize the biological functions of the molecule in vivo.
2.I am actively involved in identification of new members of the adhesion-GPCR family and the elucidation of the functions of these receptors including their specific expression patterns and the identification of their cellular ligands, etc.
3.Another area of interest in the post-translational modification of the adhesion-GPCR receptor, which involves a conserved proteolytic cleavage process and its functional role.

Education:
08/92 - 12/97 Oak Ridge Graduate School of Biomedical Sciences, University of Tennessee - Knoxville TN, U.S.A. Ph.D.
08/87 - 06/89 Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan M.S.
08/83 - 06/87 Department of Biology, National Cheng Kung University, Tainan, Taiwan B.S.

Selected Publications: *: corresponding author; &: co-first author
1.Au, L-C., Huang, Y-B., Huang, T-F., Teh, G-W., Lin, H-H., and Choo, K-B. 1991. A common precursor for a putative hemorrhagic protein and rhodostomin, a platelet aggregation inhibitor of the venom of Calloselasma rhodostoma: Molecular cloning and sequence analysis. 
2.Au, L-C., Lin, H-H., Teh, G-W., and Lin, S-B. 1992. Snake venom platelet inhibitor (Rhodostomin) inhibits cell-attachment. 
3.Lin, H-H., Sternfeld, D. C., Shinpock, S. G., Popp, R. A., and Mucenski, M. L. 1996.  Functional analysis of the c-myb proto-oncogene. 
4.Lin, H-H, L.J. Stubbs. and M.L. Mucenski. 1997. Identification and characterization of a seven transmembrane hormone receptor using differential display.
5. Stacey, M., Lin, H-H., Gordon, S., and McKnight, A. J.  2000.  LNB-TM7, a group of seven-transmembrane proteins related to family-B G-protein-coupled receptors.
6. Lin, H-H*, Stacey, M., Hamann J, Gordon, S., and McKnight, A. J. 2000. Human EMR2, a Novel EGF-TM7 Molecule on Chromosome 19p13.1, is Closely Related to CD97.
7.Stacey, M., Lin, H-H., Hilyard KL, Gordon, S., and McKnight, A. J. 2001. Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils.
8.Lin, H-H, Stacey, M., Saxby C., Knott V., Chaudhry Y., Evans D., Gordon S., McKnight AJ., Handford P., Lea S. 2001. Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex.
9.Wreschner DH, McGuckin MA, Williams SJ, Baruch A, Yoeli M, Ziv R, Okun L, Zaretsky J, Smorodinsky N, Keydar I, Neophytou P, Stacey M, Lin H-H., Gordon S. 2002 Generation of ligand-receptor alliances by "SEA" module-mediated cleavage of membrane-associated mucin proteins.
10.Kwakkenbos MJ., Chang G.-W., Lin H-H., Pouwels W., de Jong EC., van Lier RAW., Gordon S., and Hamann J 2002 The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells.

Honor and Awards:
  • 1992-1997 UT-Oak Ridge Graduate School of Biomedical Sciences, Pre-doctoral Fellowships
  • 1997 University of Tennessee - Knoxville
    Chancellor’s Citation for Extraordinary Professional Promise
    (The highest honor for a graduate student in the University)
  • 1998-2000 Wellcome Trust Cardiovascular Research Initiative Research Fellowship, U.K.
  • 2000-2002 Celltech Ltd. Senior Research Fellowship, U.K.
  • 2002-2004 British Heart Foundation Research Fellowship, UK
  • 長庚大學99-101年度國科會補助大專校院獎勵特殊優秀人才獎
  • 2012-Present Board Member, Adhesion-GPCR Consortium

Patents:
I am a co-holder of a patent: Human EMR2. (With Prof. Siamon Gordon, Dr. Andrew McKnight and Dr. Martin Stacey)