Expertise at Chang Gung System

Chun-Yen Lin ,M.D.,Ph.D.
Institution: Chang Gung Memorial Hospital
Position: Professor
Department: Hepatology and Gastroenterology
Address: No. 5, Fu-Shing Street, Kueishan, Taoyuan 333, Taiwan.
Tel:+886-3-3281200 ext:8107
E-mail: chunyenlin@gmail.com

Focus of Interest:
  • Cellular Immunology
  • Tumor Immunology
  • Viral immunology
  • Liver immunology
Research Summary

Main interest is to bridge the basic study, translational study and clinical study based on an immunological foundation. The main research fields are listed below:

  1. Basic Studies: Immune mechanisms of immune regulation: using mice model to explore the suppression mechanisms of different regulatory immune cells, including regulatory T cells, tolerogenic dendritic cells; tumor-associated macrophage and MDSC
    2. A. Immune regulation in tumor immunotherapy: using mice model to develop strategies of tumor immunotherapy, especially to block the inhibition effect of immune regulation.
    B. Immune regulation in acute liver injury: using mice model to explore the immune derangement in acute liver injury and to develop possible treatment strategies
  2. Translational Studies: Immune regulation in chronic viral hepatitis, liver cirrhosis, acute liver failure and cancer: using human studies to understand the impact of immune regulation on the disease progression and treatment outcome. The aim is to develop effective immune therapy and to develop useful immunometer for predict the disease progression.
  3. Clinical studies: Disease characteristics and treatment responses for chronic hepatitis C, chronic hepatitis B, liver cirrhosis and hepatoma. An immunological concept is the main underlying reasoning to approach these diseases.

Employment Records:
1994—Attending Physician, Division of Gastroenterology／Department of Medicine／Chang Gung Memorial Hospital; Taoyuan, Taiwan
2011－Associate Chairperson, School of Medicine, College of Medicine;Chang Gung University; Taoyuan, Taiwan

Education:
1980-1987 Doctor of Medicine (M.D.)
Taipei Medical University Taipei, Taiwan


1997-2002 Doctor of Philosophy (Ph.D.)
Sir William Dunn School of Pathology／Oxford University／Oxford, England

Selected Publications:
1. Lin YC, Mahalingam J, Chiang JM, Su PJ, Chu YY, Lai HY, Fang JH, Huang CT, Chiu CT, Lin CY*. Activated but not resting regulatory T cells accumulated in tumor microenvironment and correlated with tumor progression in patients with colorectal cancer.
2. Mahalingam J, Lin YC, Chiang JM, Su PJ, Chu YY, Lai HY, Fang JH, Huang CT, Chiu CT, Lin CY*. LAP+CD4+ T cells are suppressors accumulated in the tumor sites and associated with the progression of colorectal cancer.
3. Chang LY, Lin YC, Kan CW, Hsu CY, Chu YY, Huang CT, Day YJ, Chen TC, Yeh CT, Lin CY*. The indispensable role of CCR5 for in vivo suppressor function of CD103+ effector/memory regulatory T cells.
4. Chang LY, Lin YC, Mahalingam J, Huang CT, Chen TW, Kang CW, Peng WM, Chu YY, Chiang JM, Dutta A, Day YJ, Chen TC, Yeh CT, Lin CY*. Tumor-derived chemokine CCL5 enhances TGF-β mediated killing of CD8+ T cells in colon cancer by T regulatory cells.
5. Liu HL, Hsieh HY, Lu LA, Kang CW, Wu MF, Lin CY*. Low-Pressure Pulsed Focused Ultrasound with Microbubbles Promotes an Anticancer Immunological Response.