Cheng-Tao Lin ,M.D. 
Intitution: Chang Gung Memorial Hospital
Position:
Associated professor
Department:
Gynecological cancer 
Mail Address: No. 5, Fu-Shing Street, Kueishan, Taoyuan 333, Taiwan.
Tel: +886-3-328-1200 ext.8255
E-mail: 51424@cgmh.org.tw
Focus of Interest:- Cytokine-based cancer immunotherapy
- Immunochemoradiotherapy
- Biotherapy
- Integrated cancer therapy in clinical application
Research Summary
We administered subcutaneous route of immunomodulatory agents including of OK-432 (as adjuvant agent elicit CD83+ dendritic cells to perform phargocytosis, processing, and presenting) to recruit bodies’ immune cells, Interleukin-2 (as T cell growth factor), and interferon (as nature interferon producing cells’ product generate nature immunity). We used these drugs to elicit dendritic cells’ innate and adaptive immunity linkage to produce efficient cell-cell interaction of immunosynapse. Therefore, we final administrated oral or single agent chemotherapy drug and/ combination of chemotherapy to generate cancer cell death. Reference: Lin CT, Wang CN, Lai CH. Immunotherapy for advanced or relapsed cervical cancer. Gynecology and minimally invasive therapy 2013;2:3-7
Education:
1983-1985. Technician of Medicine, China Medical College, Taichun, Taiwan
1988-1993. Bachelor of Medical（equivalent of M.D. in U.S.）Chung-Gung Medical College, Taiwan, ROC.
Employment Records: 1999/11/01 – 2003/0/02/28 Investigator,
Pathology, immunology, Cellular and Molecular Biology Training Program at Johns Hopkins University School of Medicine Baltimore, MD USA (Wu, TC Professor)
Selected Publications:1. Lin CT, Qiu JT, Wang CJ, Chang SD, Tang YH, Wu PJ, Jung SM, Huang CC, Chou HH, Jao MS, Lai CH. Topical imiquimod treatment for human papillomavirus infection in patients with and without cervical/vaginal intraepithelial neoplasia. Taiwan J Obstet Gynecol. 2012 Dec;51(4):533-8. doi: 10.1016/j.tjog.2012.09.006.
2. I-Ju Chen, Chih-Feng Yen, Kun-Ju Lin, Chyi-Long Lee, Yung-Kuei Soong, Chyong-Huey lai, Cheng-Tao Lin (Corresponding author)Vaccination with OK-432 followed by TC-1 tumor lysate leads to significant antitumor effects Reproductive Sci 2011; Jul;18(7):687-94. doi: 10.1177/1933719110396230. Epub 2011 Feb 14.
3. Chang-Tao Lin, Chih-Feng Yen, Sheng-Wen Shaw, Tzu-Chen Yen, Yin-Ju Chen, Yung-Kuei Soong, Chyong-Huey Lai. Gene gun administration of therapeutic HPV DNA vaccination restore the efficacy of prolonged defrosted viral based vaccine. Vaccine. 2009 Sep 23. [Epub ahead of print]。
4. Lin CT, Tsai YC, He L, Yeh CN, Chang TC, Soong YK, Monie A, Hung CF, Lai CH. DNA vaccines encoding IL-2 linked to HPV-16 E7 antigen generate enhanced E7-specific CTL responses and antitumor activity. Immunol Lett. 2007 Dec 15;114(2):86-93. Epub 2007 Oct 16.
5. Lin CT, Chang TC, Shaw SW, Cheng PJ, Huang CT, Chao A, Soong YK, Lai CH. Maintenance of CD8 effector T cells by CD4 helper T cells eradicates growing tumors and promotes long-term tumor immunity. Vaccine. 2006 Sep 11;24(37-39):6199-207. Epub 2006 Jun 23.
Full Publication List
Honor and Awards: 2004 9th Annual meeting Taiwan international society for medical oncology cancer for 2004. Recombinant Vaccinia increases HPV-16 E7-expressing Sindbis Virus replicon Particles (2004 Annual Taiwan cancer oncology Gynecology excellent poster paper award)
2006 Annual promising research transfer technique award. Chung Gung Memorial hospital & University 2006
Source: Mouse strains:C57BL6
Cell lines: Cervical cancer cell line TC-1
Special technology: none