Hwang TL

Tsong-Long Hwang ,Ph.D.
Intitution: Chang Gung University
Position: Professor
Department: Graduate Institute of Natural Products
Mail Address: 259 Wen-Hwa 1 st Road, Kweishan, Taoyuan, 33302, Taiwan
Tel: +886-3-211-8800 ext.5523
E-mail: htl@mail.cgu.edu.tw

Focus of Interest:

• Neutrophilic Inflammation
• Innate immunity
• signal transduction
• Protein kinase
• Drug research and development

Research Summary
Inflammatory responses are important in host defense, however dysregulated inflammation results in tissue damage. Activated neutrophils and nonocytes play a critical role in a variety of acute and chronic inflammatory diseases. The overall goals of work in our laboratory are to understand the molecular and cellular mechanisms in neutrophil and monocyte activation and to study the pharmacological actions of bioactive compouns for developing better therapeutic strategies in immune-mediated inflammatory disorders.

Employment Records:
2000-2005 Assistant Professor, Graduate Institute of Natural Products, Chang Gung University, Taiwan
2005-2009 Associate Professor, Graduate Institute of Natural Products, Chang Gung University, Taiwan

Education:

1987-1991          BS, School of Pharmacy Kaohsiung Medical College, Taiwan
1991-1993          MS, Institute of Medicine Kaohsiung Medical College, Taiwan
1996-2000         PhD, Department of Pharmacology National Taiwan University, Taiwan

Selected Publications:

1. Yang SC, Chung PJ, Ho CM, Kuo CY, Hung MF, Huang YT, Chang WY, Chang YW, Chan KH, Hwang TL*. Propofol Inhibits Superoxide Production, Elastase Release, and Chemotaxis in Formyl Peptide-Activated Human Neutrophils by Blocking Formyl Peptide Receptor 1. J Immunol. 2013 Jun 15;190(12):6511-9.

2. Wu YC, Sureshbabu M, Fang YC, Wu YH, Lan YH, Chang FR, Chang YW, Hwang TL*. Potent inhibition of human neutrophil activations by bractelactone, a novel chalcone from Fissistigma bracteolatum. Toxicol Appl Pharmacol. 2013 Feb 1;266(3):399-407.

3. Yu HP, Hsieh PW, Chang YJ, Chung PJ, Kuo LM, Hwang TL*. 2-(2-Fluorobenzamido)benzoate ethyl ester (EFB-1) inhibits superoxide production by human neutrophils and attenuates hemorrhagic shock-induced organ dysfunction in rats. Free Radic Biol Med. 2011; 50:1737-1748.

4. Hwang TL*, Wang CC, Kuo YH, Huang HC, Wu YC, Kuo LM,  Wu YH. The hederagenin saponin SMG-1 is a natural FMLP receptor inhibitor that suppresses human neutrophil activation. Biochem Pharmacol. 2010 Oct 15;80(8):1190-200.

5. Hwang TL*, Li GL, Lan YH, Chia YC, Hsieh PW, Wu YH, Wu YC. Potent inhibition of superoxide anion production in activated human neutrophils by isopedicin, a bioactive component of the Chinese medicinal herb Fissistigma oldhamii. Free Radic Biol Med. 2009 Feb 15;46(4):520-8.

Honor and Awards:

• 2006       Ta-You Wu Memorial Award, National Science Council, Taiwan
  
• 2009       The most hightly-cited Journal of Dermatological Science paper, Elseiver.
• 2012       Research and Development Paper Award, Formosa Plastics Group, Taiwan.
• 2010 ~ Editorial Board/Advisory Editorial Board: American Journal of Current Immunology; American Journal of BioScience; Journal of Botanics: Targets and Therapy; Pharmacologia; ISRN Pharmaceutics; TANG (International Journal of Genuine Traditional Medicine); World Journal of Pharmacology; Chronicles of Surgery; American Journal of BioScience; Journal of Coastal Life Medicine