Ching-Tai Huang , M.D., Ph.D. 
Intitution: LinKou Chang Gung Memorial Hospital
Position: The chief of Infectious Diseases /Associate Professor
Department: Infectious Diseases
Address: Infectious Diseases, Medicine Chang Gung Memorial Hospital #5 Fu-Shin St., Kuei-Shen Taoyuan, Taiwan
Tel:
+886-3-3281200 ext:8450
E-mail:
chingtaihuang@gmail.com
Focus of Interest:- Influenza
- Inflammation
- cytokine storm
- Hemagglutinin-specific T cells
The influenza virus is known for its ability to cause acute febrile respiratory illness with possibility of severe morbidity and mortality in humans. Host immune response contributes to the disease in addition to the damage resulted from invasion of the virus. Cytokine storm with activation of the innate and the antigen specific acquired immunity is a major concern. In our transgenic mouse model system, influenza hemagglutinin (HA)-specific T cells respond to influenza virus infection and produce effector cytokines with both facilitated viral clearance and aggravated lung inflammation. Adoptive transfer of HA-specific naïve CD8+ T cells causes mortality with sub-lethal dose of influenza virus infection in mice. Co-transfer of HA-specific naïve CD4+ T cells impedes this lethal effect. The HA-specific CD4+ T cells have regulated the activity of effector CD8+ T cells. Balanced effector and regulatory arms of antigen-specific CD4+ T cells will provide efficient virus eradication without undesired tissue damage by the immune response. We will seek to dissect the molecular mechanisms responsible for maintenance of such an optimized balance. Identification of key molecules for the balance will offer diagnostic and therapeutic applications for severe influenza illness in humans.
Employment Records:2010 ~ present Director
Division of Infectious Diseases, Department of Medicine
Chang Gung University School of Medicine and Hospital, Taipei, Taiwan
2005 ~ present Associate Professor
Division of Infectious Diseases, Department of Medicine
Chang Gung University School of Medicine and Hospital, Taipei, Taiwan
2004 ~ 2005 Assistant Professor
Division of Infectious Diseases, Department of Medicine
Chang Gung University School of Medicine and Hospital, Taipei, Taiwan
2002 ~ 2004 Faculty
Research Associate
The Sydney Kimmel Comprehensive Cancer Center at Johns Hopkins
The Johns Hopkins University School of Medicine, Baltimore, Maryland, U. S. A.
1994 ~present Attending Physician
Division of Infectious Diseases, Department of Medicine
Chang Gung University School of Medicine and Hospital, Taipei, Taiwan
Education:
1980-1987 Doctor of Medicine (M.D.)
Taipei Medical University
Post- Graduate Education
1996-2001 Doctor of Philosophy (Ph.D.)
Biochemistry, Cellular and Molecular Biology Training Program
Johns Hopkins University School of Medicine
Bltimore, MD, U.S.A
Selected Publications:
1. Altered T-bet dominance in interferon-r decoupled CD4+ T cells with attenuated cytokine storm and preserved memory in influenza
The Journal of Immunology 2013
2. Egr-2 and Egr-3 are negative regulators of T cell activation
Nature Immunology 2005;6:472-480
3. Role of LAG-3 in regulatory T cells
Immunity 2004;21:503-513
4. Persistent Toll-like receptor signals are required for reversal of regulatory T cell- mediated CD8+ T cell tolerance
Nature Immunology 2004;5:508-515
5. CD4+ T cells pass through an effector phase during the process of in vivo tolerance induction
The Journal of Immunology 2003;170:3945-3953
Full Publication List
Resource:
Mouse strains: Transgenic C57/B10D2 and Balb/c mice
Cell lines: MDCK
Special technology:
1. The influenza hemagglutinin (HA)-specific transgenic mouse system.
2. Influenza Virus infection and monitoring
3. Flow cytometry system