Expertise at Chang Gung System

Shih, Lee-Yung , M.D.
Institution: Linkou Chang Gung Memorial Hospital  / Chang Gung University
Position: Physician / Professor
Department: Hematology
Address: No.5, Fusing St., Gueishan Township, Taoyuan County 333, Taiwan (R.O.C.)
Tel: +886-3-3281200 ext.2524
E-mail: sly7012@cgmh.org.tw

Focus of Interest:
  • Hematopoietic Disorder
  • Hematological Malignancies
  • Molecular Diagnosis

Employment Records:
1987/8~present, Professor, Chang Gung University
1978/7~present, Attending Physician, Division of Hematology-Oncology, Chang Gung Memorial Hospital
1985/4~2006/6, Director, Division of Hematology-Oncology, Chang Gung Memorial Hospital


Education:
National Taiwan University, Taipei, Taiwan


Selected Publications:
  1. Shih LY*, Huang CF, Wu JH, Lin TL, Dunn P, Wang PN, Kuo MC, Lai CL, Hsu HC. Internal tandem duplication of FLT3 in relapsed acute myeloid leukemia: A comparative analysis of bone marrow samples from 108 adult patients at diagnosis and relapse. Blood. 2002, 100:2387-2392.
  2. Shih LY*, Liang DC, Fu JF, Wu JH, Wang PN, Lin TL, Dunn P, Kuo MC, Tang TC, Lin TH, Lai CL. Characterization of fusion partner genes in 114 patients with de novo acute myeloid leukemia and MLL rearrangement. Leukemia. 2006, 20:218-223.
  3. Sanada M, Suzuki T, Shih LY* (co-first and co-corresponding author), Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S*. Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature. 2009, 460: 904-908.
  4. Kuo MC, Liang DC, Huang CF, Shih YS, Wu JH, Lin TL, Shih LY* . RUNX1 mutations are frequent in chronic myelomonocytic leukemia and mutations at C-terminal region predict acute myeloid leukemia transformation. Leukemia. 2009, 23:1426-1431.
  5. Liang DC, Liu HC, Yang CP, Jaing TH, Hung IJ, Yeh TC, Chen SH, Hou JY, Huang YJ, Shih YS, Huang YH, Lin TH, Shih LY* . Cooperating gene mutations in childhood acute myeloid leukemia with special reference on the mutations of ASXL1, TET2, IDH1, IDH2 and DNMT3A. Blood. 2013, 121: 2988-2995.


Board Certification/Professional Affiliations:
Hematology, Taiwan
Internal Medicine, Taiwan

Ongoing Projects:

  1. Genetic aberrations in adult B-precursor acute lymphoblastic leukemia: characterization of clinically relevance subtypes and functional study on novel mutants identified
  2. Pathogenesis of cooperating mutations of partial tandem duplication of MLL gene in de novo acute myeloid leukemia
  3. Translational research for improving cancer patient survival in Taiwan: A multiple center approach (Blood cancer program:acute myeloid leukemia)