Expertise at Chang Gung System

Shi, Chung-Sheng ,Ph.D.
Institution: Chang Gung University
Position: Assistant professor
Department: Graduate Institute of Clinical Medical Sciences
Address: No.6, W. Sec., Jiapu Rd., Puzi City, Chiayi County 613, Taiwan (R.O.C.)
Tel: 886-53621000#2100
E-mail: csshi@mail.cgu.edu.tw

Focus of Interest:
  • Biochemistry and Molecular Biology - Medicine
  • Oncology
  • Stem cell

Fulltime Employment:
  • 2010/09~present: Assistant Professor: Study the role of thrombomodulin in mesenchymal stem cells (MSCs). (Graduate Institute of Clinical Medical Sciences, Chiayi branch, Chang Gung University, Tainan, Taiwan)
  • 2008/10~2010/06: Researcher: Development of the therapeutic monoclonal antibody, phage display platform and pharmacokinetic transgenic animal model. (AbGenomics International Inc., Taipei, Taiwan)
  • 2007/10 ~ 2008/10: Project-Appointed Assistant Professor: Characterization of human thrombomodulin lectin-like domain in sepsis. (work as a researcher in Cardiovascular Research Center and Department of Biochemistry and Molecular Biology, National Cheng Kung University, Tainan, Taiwan)
  • 2006/02 ~ 2007/09: Postdoctoral Fellow: Characterization of human thrombomodulin domains in atherosclerosis and acute inflammation. (work as Postdoctoral researcher in Prof. Hua-Lin Wu’s Lab, Department of Biochemistry and Molecular Biology, National Cheng Kung University, Tainan, Taiwan)

Education:
  • 2002/09 ~ 2006/01: Ph.D. Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Thesis Advisor: Guey-Yueh Shi, Ph.D.
  • 1996/09 ~ 1998/06: Master of Science. Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Thesis Advisor: Hua-Lin Wu, Ph.D.
  • 1994/09 ~ 1996/06: Bachelor of Science. Department of Microbiology, SooChow University, Taipei, Taiwan.

Honors and Awards:
  • The Third Fall Camp of Taiwan Society for Biochemistry and Molecular Biology, Tainan, Poster Competition Award (2003).
  • College of Medicine, National Cheng Kung University Outstanding Research Award (2005).
  • The Taiwan Society for Biochemistry and Molecular Biology Poster Competition Award (2005).
  • Professor Jung-Yaw Lin Academy Foundation Thesis Award (2005).
  • National Science Council Outstanding Technology Transfer Contribution Prize (2005).

Selected Main Publications:
  1. Shi CS, Shi GY, Chang YS, Han HS, Kuo CH, Liu C, Huang HC, Chang YJ, Chen PS, Wu HL.  Evidence of human thrombomodulin domain as a novel angiogenic factor.  Circulation. 2005 Apr 5; 111(13): 1627-36. (SCI:; subject categories in CARDIAC & CARDIOVASCULAR SYSTEMS: 2/125; PERIPHERAL VASCULAR DISEASE: 1/65.  Journal Citation Reports® 2013)
  2. Shi CS, Huang HC, Wu HL, Kuo CH, Chang BI, Shiao MS, Shi GY.  Salvianolic acid B modulates hemostasis properties of human umbilical vein endothelial cells.  Thromb Res. 2007; 119 (6): 769-775. (SCI; subject categories in HEMATOLOGY: 35/68; PERIPHERAL VASCULAR DISEASE: 34/65.  Journal Citation Reports® 2013)
  3. Shi CS, Shi GY, Hsiao SM, Kao YC, Kuo KL, Ma CY, Kuo CH, Chang BI, Chang CF, Lin CH, Wong CH, Wu HL.  Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response.  Blood. 2008 Nov 1;112(9):3661-70. (SCI; subject categories HEMATOLOGY: 2/68.  Journal Citation Reports® 2013)
  4. Kao YC, Wu LW, Shi CS, Chu CH, Huang CW, Kuo CP, Sheu HM, Shi GY, Wu HL.  Downregulation of thrombomodulin, a novel target of Snail, induces tumorigenesis through epithelial-mesenchymal transition.  Mol Cell Biol. 2010; 30: 4767-4785. (SCI; subject categories in Cell Biology: 50/185; subject categories in BIOCHEMISTRY & MOLECULAR BIOLOGY: 55/291.  Journal Citation Reports® 2013)
  5. Lin WL, Chang CF, Shi CS, Shi GY, Wu HL.  Recombinant lectin-like domain of thrombomodulin suppresses vascular inflammation by reducing leukocyte recruitment via interacting with Lewis Y on endothelial cells. Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2366-73. (SCI; subject categories PERIPHERAL VASCULAR DISEASE: 9/65.  Journal Citation Reports® 2013)

All Publications List