Expertise at Chang Gung System

Chen, Hung-Chi , M.D.
Institution: Linkou, Chang Gung Memorial Hospital
Position: Physician / Associate Professor
Department: Ophthalmology
Office Address: No.5, Fuxing Street, Guishan District, Taoyuan City 33305, Taiwan
E-mail: mr3756@cgmh.org.tw
Tel:+886-3-3281200-8674
Fax:+886-3-3287798

Focus of Interest:
  • Ophthalmology
  • Stem cell
  • Tissue Engineering


Employment Record:
1999/06 – 2003/06 Residency, Department of Ophthalmology, Chang Gung Memorial Hospital
2003/07 – 2004/06 Fellowship, Division of Cornea, Department of Ophthalmology, Chang Gung Memorial Hospital
2010/08 – 2011/07 Visiting Scholarship, Department of Research and Development, Ocular Surface Center, Miami, FL, USA.

Education:
2012, Ph.D., Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan
1997, M.D., Department of Medicine, National Yang-Ming University College of Medicine, Taipei, Taiwan

Honors and Awards:
1. Membership (2013/06/01) of the Phi Tau Phi Scholastic Honor Society @ the Chang Gung University Chapter.
2. Gold Medal (2011/11/27) in Poster Award (Basic Section) @ the 52nd Annual Congress of the Ophthalmologic Society of Taiwan, Taipei, Taiwan.
3. Gold Medal (2011/11/27) in Poster Award (Clinical Section) @ the 52nd Annual Congress of the Ophthalmologic Society of Taiwan, Taipei.
4. Gold Medal (2010/12/12) in Paper Award (Alcon sponsored) @ the 51st Annual Congress of the Ophthalmologic Society of Taiwan, Taipei.

Selected Main Publications:

1. Hsueh YJ, Chen HC, Wu SE, Wang TK, Chen JK, Ma DHK* (2015) Lysophosphatidic acid induces YAP-promoted proliferation of human corneal endothelial cells via PI3K and ROCK pathways. Mol. Ther. Methods Clin. Dev.2:15014.
2. Hsueh YJ, Chen HC, Lai JY, Chen JK, Ma DHK* (2015) Corneal neovascularization as a target for nucleotide-based therapies. J. Clin.Exp. Ophthalmol.6:2.
3. Zhu YT, Chen HC, Chen SY, Tseng SCG* (2012) Nuclear p120-catenin unlock mitotic block of contact-inhibited human corneal endothelial monolayers without disrupting adherent junction. J. Cell Sci. 125(15):3636-3648. 
4. Chen HCJ, Yeh LK, Tsai YJ, Lai CH, Chen CC, Lai JY, Sun CC, Chang G, Hwang TL, Chen JK, Ma DHK* (2012) Expression of angiogenesis-related factors in human corneas after cultivated oral mucosal epithelial transplantation. Invest. Ophthalmol. Vis. Sci. 53:5615-5623. 
5. Chen HC, Zhu YT, Chen SY, Tseng SCG* (2012) Selective activation of p120ctn-Kaiso signaling to unlock contact inhibition of ARPE-19 cells without epithelial-mesenchymal transition. PLoS ONE 7(5):e36864. 



Board Certification
1. Board certified by Ophthalmologic Society of Taiwan (No. 001354) and issued by Department of Health, Executive Yuan, Taiwan
2. Medical License certified by Examination Yuan and issued (No. 028613) issued by Department of Health, Executive Yuan
3. The Formosan Medical Association - Taiwan (Registration No.: 1979)
4. The Ophthalmologic Society of Taiwan (OST) - Taiwan (A1258)
5. The Taiwan Medical Association – Taiwan (Registration No.: 8808-0062)
6. The Taiwanese Society of Cataract and Refractive Surgery (TSCRS) - Taiwan (Registration No.: 05-0219s)
7. The Taiwan Society of Stem Cell Research (TSSCR) – Taiwan (A101-5)
8. The Association of Research in Vision and Ophthalmology (ARVO) - USA (Registration No.: 77700)

Ongoing projects:
1. CMRPG3D0901 since 2014/02/01 Topic: Ex vivo expansion of putative human corneal endothelial stem cells for transplantation.
2. CMRPG 3C0531 since 2013/03/01 Topic: Selective activation of p120-catenin/Kaiso pathway to unlock the mitotic block for engineering human corneal endothelium.
3. NMRPG 101-2325-B-182A-010 since 2012/07/01 Topic: Cultivated oral mucosal epithelial cells for the treatment of ocular surface diseases, Phase II clinical trial.