Expertise at Chang Gung System

Lai, Ming-Chih ,Ph.D.
Institution: Chang Gung University
Position: Assistant professor
Department: Department of Biomedical Sciences
Address: No.259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 333, Taiwan (R.O.C.)
Tel: +886-3-3281200 #3354 Fax: +886-3-2118700
E-mail: mclai@mail.cgu.edu.tw

Focus of Interest:
  • Biochemistry and Molecular Biology - Medicine

Fulltime Employment:
  • Assistant Professor (2014-present) Department of Biomedical Sciences, Chang Gung University
  • Assistant Researcher (2010-2014) Department of Physiology, National Cheng Kung University
  • Postdoctoral Fellow (2008-2010) Institute of Biomedical Sciences, Academia Sinica
  • Research Assistant (1997-2008) Institute of Biomedical Sciences, Academia Sinica
  • Research Assistant (1996-1997) Department of Medical Research and Education, Taipei Veterans General Hospital

Education:
  • Ph.D. (2008) Institute of Life Sciences, National Defense Medical College
  • M.S. (1994) Institute of Biomedical Science, National Tsing Hua University
  • B.S. (1992) Department of Food Science, NationalChungHsingUniversity

Honors and Awards:
  • 2008 Excellent Poster Award, The 16th Symposium on Recent Advances in Cellular and Molecular Biology
  • 2006 Excellent Thesis Award & The President Award, The 1stTienTe Lee Medical Technology Award
  • 2001 Second-class Research Award, National Science Council
  • 2000 Second-class Research Award, National Science Council

Selected Main Publications:
  1. M. -C. Lai, S. -W. Wang, L. Cheng, W. -Y. Tarn, S. -J. Tsai and H. S. Sun. Human DDX3 interacts with the HIV-1 Tat protein to facilitate viral mRNA translation. PLOS ONE (2013) 8: e68665
  2. M. -C. Lai, W. -C. Chang, S. -Y. Shieh and W. -Y. Tarn. DDX3 regulates cell growth through translational control of cyclin E1. Mol. Cell. Biol. (2010) 30: 5444-5453
  3. M. -C. Lai, Y. -H. Wu Lee and W. -Y. Tarn. The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control. Mol. Biol. Cell (2008) 19: 3847-3858
  4. M. -C. Lai, H. -W. Kuo, W. -C. Chang and W. -Y. Tarn. A novel splicing regulator shares a nuclear import pathway with SR proteins. EMBO J. (2003) 22: 1359-1369
  5. M. -C. Lai, R. -I. Lin and W. -Y. Tarn. Transportin-SR2 mediates nuclear import of phosphorylated SR proteins. Proc. Natl. Acad. Sci. USA (2001) 98: 10154-10159

 

All Publications List

Board Certification:
  • The RNA Society (USA)