ANAEROBES

JAN. ~ JUN., 2003

ANTIBIOTICS \ BACTERIA

 B. fragilis B. thetaiotaomicron Clost. difficile Clost. perfringens Fusobacterium spp. Fusob. nucleatum G(+) no spore forming bacilli Peptostreptococcus spp. Peptostrepto. anaerobius Peptostrepto. magnus Peptostrepto. micros Prevotella spp. Prevotella disiens Prevotella intermedia Prevotella melaninogenica Propionibacterium spp. Propionibacterium acnes Veillonella alcalescens Veillonella parula
TOTAL TESTED NO.* 383 136 43 57 45 71 113 264 137 134 131 380 43 50 62 46 78 159 50
PERCENT OF SUSCEPTIBILITY** CHLORAMPHENICOL 100 100 64 100 100 100 100 99 94 99 100 100 100   100 100 100 100 100
CLINDAMYCIN 51 28 53 98 93 100 94 83 53 74 100 73 42 90 66 98 97 89 98
METRONIDAZOLE 100 100 100 98 100 100 91 98 100 100 100 100 100 100 100 37 1 100 100
PENICILLIN-G 0 1 77 96 80 97 93 92 40 97 98 45 5 34 16 98 100 82 92
PIPERACILLIN 67 31 100 100 93 100 100 100 99 100 100 87 88 98 85 100 100 97 96

　

GRAM (-) BACILLI
JAN. ~JUN., 2003

ANTIBIOTICS \ BACTERIA

 Acinetobacter spp. Acinetob. baumannii Acinetob. junii Aeromonas hydrophila Branhamella catarrhalis Citrob. diversus Citrob. diversus-ESBL# Citrob. freundii Citrob. freundii-ESBL# Eikenella corrodens E. coli E. coli-ESBL Enterob. aerogenes Enterob. aerogenes-ESBL# Enterob. cloacae Enterob. cloacae-ESBL# H. influenzae H. parainfluenzae Kleb. oxytoca Kleb. oxytoca-ESBL Kleb. pneumoniae Kleb. pneumoniae-ESBL Morganella morganii Morganella morganii-ESBL# Proteus mirabilis Proteus mirabilis-ESBL# Proteus vulgaris Pseudomonas spp. Ps. aeruginosa Sal. choleraesuis Sal. enteritidis B Sal. enteritidis D Serratia marcescens Stenotropho. maltophilia NOSOCOMIAL ISOLATES ONLY
Acinetob. baumannii Acinetobacter spp. Enterob. cloacae Enterob. cloacae-ESBL# E. coli E. coli-ESBL Kleb. pneumoniae Kleb. pneumoniae-ESBL Serratia marcescens Stenotrophomonas maltophilia
TOTAL (no.)* 264 1460 40 94 127 132 7 222 21 65 4938 438 128 10 485 163 719 57 155 17 1674 284 390 18 696 49 154 109 2660 30 131 61 560 435 159 55 76 41 393 92 119 49 252 69
PERCENT OF SUSCEPTIBILITY** AN 31 31 48 98 - 100 29 95 48 64 99 72 98 10 91 47 100 - 100 82 98 37 97 33 98 43 99 48 93 - - - 66 9 38 13 87 53 98 73 97 31 92 49
AM - - - 1 - 0 0 3 0 100 22 0 2 0 1 - 30 65 0 0 0 0 0 0 39 0 3 50 - 0 27 93 0 - - - 1 0 13 0 0 0 - 0
CZ - - - 7 - 92 0 7 0 97 82 0 10 0 2 0 - - 63 0 94 0 2 0 80 0 3 50 - - - - 0 - - - 4 0 71 0 89 0 - 0
CAZ 30 31 50 97 - 96 57 65 29 95 93 0 80 60 69 - - 98 100 0 98 0 87 67 100 76 99 85 89 - - - 94 40 34 15 51 5 84 0 95 0 88 94
CXM - - - 90 100 87 0 60 0 91 88 0 70 0 59 0 99 - 96 6 94 0 4 0 97 0 8 50 - - - - 2 - - - 47 0 79 0 90 0 - 0
CIP 33 32 60 93 - 100 86 90 76 100 83 55 97 80 92 83 - - 98 88 94 51 86 78 94 63 99 69 85 37 97 100 62 77 38 15 88 80 71 41 91 43 84 67
GM 25 21 38 97 - 95 14 73 5 92 74 29 95 0 77 5 - - 97 12 94 15 55 6 73 4 93 38 79 - - - 48 - 26 9 71 5 64 25 91 18 77 43
IPM 86 80 88 69 - 100 100 100 100 100 100 100 99 1000 100 100 - - 100 100 100 100 100 100 100 100 100 83 88 - - - 100 - 81 73 100 100 100 100 100 100 88 100
PIP 19 20 43 57 - 70 0 49 0 92 31 0 69 0 62 0 - 58 76 0 46 0 74 0 75 0 89 83 85 - - - 42 - 14 13 47 0 25 0 39 0 84 36
SXT - - - 79 70 94 14 67 14 85 41 23 90 10 70 9 44 98 92 6 82 13 38 11 36 2 67 50 - 13 76 92 45 76 - - 64 5 38 23 82 6 - 36
AMC - - - - 100 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
ATM 2 1 15 98 - 98 14 66 0 88 94 2 81 0 70 0 - - 99 - 98 - 93 61 100 73 98 30 82 - - - 59 - 1 2 55 0 87 0 96 0 85 45
FEP 34 31 55 - - - - - - - - - - - - - - - - - - - - - - - - 72 93 - - - - - 38 13 - - - - - - 92 -
CFM - - - - - - - - - - - - - - - - - 100 - - - - - - - - - - - 93 99 98 - - - - - - - - - - - -
CRO - - - 91 100 96 0 65 5 98 92 0 78 0 68 2 100 68 99 0 98 - 93 0 100 0 95 75 - 100 99 100 44 - - - 50 0 84 0 96 0 - 41
C - - - - - - - - - - - - - - - - 55 - - - - - - - - - - - - 10 23 89 - - - - - - - - - - - -
FLO - - - - - - 100 - 40 - 21 - - 56 2 52 - - 100 93 - 96 31 47 - 96 - - - - - - - - - - - 44 - 84 - 95 - -
 AN=amikacin; AM=ampicillin; CZ=cephazolin; CAZ=ceftazidime; CXM=cefuroxime; CIP=ciprofloxacin; GM=gentamicin; IPM=imipenem; PIP=piperacillin; SXT=sulfamethoxazole-trimethoprim 

 AMC=amoxicillin/clavulanic acid; ATM=aztreonam; FEP=cefepime; CFM=cefixime; CRO=ceftriaxone; C=chloramphenicol; P=penicillin; TE=tetracycline; FLO=flomoxef; NA=nalidixic acid; F/M=nitrofurantoin 

 - =not tested or not available

 #根據NCCLS guideline, 所有會產生ESBLs的Klebsiella spp.及E. coli即使in vitro對penicillins, cephalosporins, 或aztreonam具敏感性, 但在臨床治療上可能對這些藥物實際上是抗藥的, 因此若經過標準方法確認為ESBLs的菌株, 對於這類藥物的藥敏結果均應改成非敏感性.

 其他腸內菌科的細菌, 如Citrobacter spp., Enterobacter spp., Morganella spp., Proteus spp.等, 雖然目前NCCLS guideline仍未有關於ESBL鑑定及確認等的相關建議, 但文獻上已有不少相關報導, 故本科亦依現有方法進行相關的檢測, 但藥敏性仍維持in vitro測試所得的結果 

 結果僅供臨床醫師參考, 實際使用時仍應注意病人反應, 隨時調整用藥. 

　

GRAM (+) BACTERIA
JAN. ~ JUN., 2003

ANTIBIOTICS \ BACTERIA

 Enterococcus spp. Enterococcus faecalis Enterococcus faecium Enterococcus raffinosus Staph. aureus Staph. epidermidis Staph. saprophyticus Coag. (-) staphylococci Strep. pneumoniae Beta strep. non A,B,D Beta strep. group B Strep. group D Viridans streptococci NOSOCOMIAL ISOLATES ONLY
Coag. (-) staphylococci Enterococcus faecalis Enterococcus faecium Staph. aureus-R Staph. aureus-S Viridans streptococci
　
TOTAL TESTED NO.* 96 1552 291 84 3926 110 77 2008 311 172 606 183 777 153 177 39 324 105 64
PERCENT OF SUSCEPTIBILITY** AMPICILLIN 84 99 33 73 - - - - - - - - - - 99 5 - - -
CEFTRIAXONE - - - - - - - - 89 98 99 86 94 - - - - - 95
CEFUROXIME - - - - - - - - 28 - - - - - - - - - -
CLINDAMYCIN - - - - 29 60 - 53 - 82 47 53 62 44 - - 4 92 63
ERYTHROMYCIN - - - - 25 20 - 29 - 77 49 56 47 28 - - 1 90 47
OXACILLIN - - - - 32 11 5 21 - - - - - 11 - - 0 100 -
PENICILLIN-G - - - - 2 7 6 6 53 98 99 86 80 6 - - 0 5 77
SXT - - - - 52 55 66 57 - - - - - 49 - - 25 99 -
TEICOPLANIN 95 100 87 100 100 100 100 100 - 100 100 100 100 99 100 87 100 100 100
VANCOMYCIN 94 99 86 100 100 100 100 100 100 100 100 100 100 100 99 87 100 100 100
 High level gentamicin susceptibility:

  Enterococci    46.7% (438/937)

Penicillin-G susceptibility:

  Strep. pneumoniae (BF:61)    Susceptible: 31.15% (19); Relative resistant: 37.70% (23); Resistant: 31.15% (19) ( MIC S: <=0.06, I: 0.12-1, R: >=2)

  Strep. pneumoniae (othes:250)    Susceptible: 58.40% (146); Relative resistant: 28.40% (71); Resistant: 13.20% (33) ( MIC S: <=1, I: 2, R: >=4)

SXT = Sulfamethoxazole-Trimethoprim

  - = not tested or not available