Pei’s Somatosensory Laboratory
Chang Gung Memorial Hospital and Chang Gung University
- A lab for neural coding
People
Principal Investigator: Yu-Cheng Pei, MD PhD (裴育晟)
Attending Physician
Department of Physical Medicine and Rehabilitation,
Assistant Professor,
Email: yspeii@adm.cgmh.org.tw
Tel:+886-3-3281200 ext 3846
Fax:+886-3-3281200 ext 2667
Education: PhD, Department of Neuroscience,
Johns Hopkins University, Baltimore, USA
Postdoctoral Fellow: Hsin-Yi Lai PhD (賴欣怡)
Email: happydry@ms36.hinet.net
Webpage: http://hsinyilai.blogspot.tw
Education: PhD, Dept of Electrical Control Engineering,
National Chiao Tung University, Hsinchu, Taiwan
Senior Research Assistant: Ya-Huei Hsu, MS (許雅惠)
Email: mhog0jip@gmail.com
Education: MS, Dept of Cognitive Science,
National Cheng Kung University, Tainan, Taiwan
Senior Research Assistant: Ting-Yu Chang, MS (張廷宇)
Email: taiwan.changty@gmail.com
Education: MS, Dept of Power Mechanical Engineering
National Tsing Hua University, Hsinchu, Taiwan
Senior Research Assistant: You-Ping Yang, MS (楊幼屏)
Email: b92207021@gmail.com
Education: MS, Dept of Psychology
Research Assistant: Ya-Ting Chang, MS (張雅婷)
Email: pekocola@gmail.com
Education: MS, Dept of Veterinary Medicine,
Research Assistant: Yao-CHou Cheng (Vincent), MS (陳耀主)
Email: arteriovenous@gmail.com
Education: MS, Dept of Psychology,
Research Assistant: Ming-Shih Lin, BS (林明蒔)
Email: obs22392349@gmail.com
Education: BS, Dept of Veterinary Medicine,
Research Assistant: Ke-Ting Chen, MS (陳可庭)
Email: ketingchen1126@gmail.com
Education: MS, Dept of Biomedical Engineering,
Research Assistant: Ting-Yu Chen, MS (陳亭伃)
Email: yu89999@hotmail.com
Education: MS,
Research Assistant and Music Therapist: Hsin-Yi Cheng, MA, MT-BC (鄭心怡)
Email: hsinyi0936@gmail.com
Education: MA, Department of Music Therapy
The
PhD student: Wei-Han Chang, MD (張韡瀚)
Email: m7252@adm.cgmh.org.tw
PhD Program: PhD program of Biomedical Engineering,
Bachelor student: Ji-Lin Chen (陳吉麟)
Email: mr.frog14@yahoo.com.tw
Bachelor program: Department of Biomedical Engineering
Research
Neural coding for tactile motion
We
focus on neural coding in tactile perception. Specifically, we combine
psychophysics, cortical neurophysiology and computational methods to understand
the neuronal mechanism of the motion processing in the primary somatosensory
cortex. Using tactile stimulus inspired by visual experiments such as gratings,
plaids and random dot displays, we have shown that the somatosensory system
integrates local motion signals to form a holistic motion percept (
Computational modeling for motion integration
We develop physiologically plausible computation models that can account for motion integration, a nonlinear processing performed as motion information ascends the processing hierarchies. We proposed a terminator-based vector average model that predicts tactile motion percept to moving contours (Pei et al. Neuron 2011).
Novel neuromodulation models
We investigate the neuromodulation induced by focused ultrasound (FUS). Its effects are evaluated by somatosensory evoked potentials, blood-oxygen-level dependent signals and behaviors. This line of inquiry will contribute to the treatment of disease and the understanding of physiological processing in the central nervous system. The laboratory will keep applying novel neuroengineering methods to allow us to solve the unsolved problems in system neuroscience.
Publication
Selected Publications
(in press) Pei Y*, Lee TC, Chang TY, Ruffatto D, Spenko M, Bensmaia S. A multi-digit tactile motion stimulator. J Neurosci Methods 2014 (Grant: NSC 99-2320-B-182A-003-MY2 and NSC 99-2321-B-182A-004, CMRPG590021G and BMRP390021, EMRPD1A0861). (IF: 2.114; ranked 170/252 in Neurosciences)
(in press) Pei Y, Fang TJ, Li HY, Wong AM. Cricothyroid muscle dysfunction impairs vocal fold vibration in unilateral vocal fold paralysis. Laryngoscope. 2013 [Epub ahead of print] (IF: 1.979; ranked 7/43 in Otorhinolaryngology) (Grant: NSC 100–2314-B-182-021)
Huang LT, Wong AMK., Chen CPC, Chang WH, Cheng JW, Lin YR, Pei Y*. Global motion percept mediated through integration of barber-poles presented at bilateral visual hemifields. PLoS One. 2013 Aug; 8(8): e74032. (IF: 3.73; ranked 7/56 in Multidisciplinary sciences). (Grant: CMRPG100-0536C)
Pei Y*, Chang TY, Lee TC, Saha S, Lai HY, Gomez-Ramirez M, Chou SW, and Wong AMK. Cross-modal sensory integration of visual-tactile motion information: instrument design and human psychophysics. Sensors. 2013:13:7212-7223. (IF: 1.95; ranked 9/57 in Instruments & instrumentation). (Grant: NSC 100-2321-B-182A-002, CMRPG590022G)
Pei Y, Hsiao SS, Craig JC, Bensmaia SJ. Neural mechanisms of tactile motion integration in primary somatosensory cortex. Neuron. 2011; 69(3):536-547. (IF: 15.77; ranked 5/251 in Neurosciences category) (Grant: CMRPG350963)
Pei Y, Hsiao SS, Craig JC, Bensmaia SJ. Shape invariant coding of motion direction in primary somatosensory cortex. PLoS Biology. 2010;8(2):e1000305 (IF: 12.69; ranked 1/83 in Biology category) (Grant: CMRPG350963)
Pei Y, Denchev PV, Hsiao SS, Craig JC, Bensmaia SJ. Convergence of submodality specific input onto neurons in primary somatosensory cortex J. Neurophysiol. 2009 Jun;102(3):1843-53. (IF: 3.30; ranked 22/79 in Physiology category) (Grant: CMRPG350963)
Pei Y, Hsiao SS, Bensmaia SJ. The tactile integration of local motion cues is analogous to its visual counterpart. Proc Natl Acad Sci USA. 2008 Jun 10;105(23):8130-5. (IF: 9.74; ranked 4/56 in Multidisplinary Sciences category) (Grant: CMRPG350963)
Fu T, Wong AMK, Pei Y*, Wu KP, Chou S, Lin Y. Effect of Kinesio taping on muscle strength in athletes-a pilot study. J Sci Med Sport. 2008 Apr ;11(2):198-201. (IF: 2.90; ranked 10/84 in Sport Sciences category)
Pei Y, Chen C, Chung C, Chou S, Wong AMK, Tang SFT. Pre-attentive mental processing of music expectation: event-related potentials of a partially violating and resolving paradigm. Brain Cogn. 2004 Feb ;54(1):95-100. (IF: 2.82; ranked 131/251 in Neurosciences category).
* Corresponding author
Other publications
(in press) Chen CK, Pei Y, Chen NH, Huang LT, Chou SW, Wu KP, Ko PC, Wong AMK. Sedative Music Facilitates Deep Sleep in Young Adults. Journal of Alternative and Complementary Medicine. 2013:[online ahead of print](IF: 1.46; ranked 10/21 in Integrative and complementary medicine)
Chang WH, Wu CK, Pei Y, Chen CC, Wong AMK. The treatment of pain with heel fat pad syndrome by hyaluronic acid injection: a case report. Tw J Phys Med Rehabil 2013; 41(1): 59-67. (Domestic peer-reviewed journal)
Cheng HYK, Lien YJ, Yu YC, Ju YY, Pei Y, Cheng CH, Wu DBC. The effect of lower body stabilization and different writing tools on writing biomechanics in children with cerebral palsy. Research in Developmental Disabilities. 2013:34: 1152-1159. (IF: 2.48; SSCI journal)
Tsai WL, Wong AMK, Pei Y, Lin YR, Liao YH, Huang SC. Application of Digital Volume Pulse Analysis in Patients with Spinal Cord Injury. Tw J Phys Med Rehabil. 2012;40(4):189-196. (Domestic peer-reviewed journal)
Wong AMK, Chang WH, Ke PC, Huang CK, Tsai TH, Chang HT, Shieh WY, Chan HL, Chen CK*, Pei Y*. Technology Acceptance for an Intelligent Comprehensive Interactive Care (ICIC) System for Care of the Elderly: A Survey-Questionnaire Study. PLoS One 2012:7(8): e40591. (IF: 3.73; ranked 7/56 in Multidisciplinary sciences). (Grant: GMRPD150123)
Chen SW, Lin SH, Liao LD, Lai HY, Pei Y, Kuo TS, Lin CT, Chang JY, Chen YY, Lo YC, Chen SY, Wu Robby and Tsang Siny. Quantification and recognition of parkinsonian gait from monocular video imaging using kernel-based principal component analysis. BioMedical Engineering OnLine 2011;Nov 10(99):e1-21. (IF: 1.61; ranked 39/79 in Engineering, Biomedical category). (Grant: NSC 99-2628-E-010-002, NSC 100-2628-E-009-007)
Wang TN, Lin KC, Wu CY, Chung CY, Pei Y, Teng YK. Validity, responsiveness, and clinically important difference of the ABILHAND questionnaire in patients with stroke. Arch Phys Med Rehabil. 2011 Jul;92(7):1086-91. (IF: 2.36; ranked 9/63 in Rehabilitation category). (Grant: NHRI-EX99-9920PI, NHRI-EX99-9742PI, NSC 97-2314-B-002-008-MY3, NSC 99-2314-B-182-014 -MY3)
Wong AM, Chou S, Huang S, Lan C, Chen H, Hong W, Chen CP, Pei Y*. Does Different Exercise Have the Same Effect of Health Promotion for Elderly?--Comparison of Training-specific Effect of Tai Chi and Swimming on Motor Control. Arch Gerontol Geriatr. 2011 Sep-Oct;53(2):e133-7. (IF: 1.70; ranked 30/46 in Geriatrics & gerontology category) (Grant: NSC 95-2314-B-182A-005-)
Wang CM, Yang JY, Hsueh PY, Pei Y, Tsai CF, Wu KP A Case Report of Bilateral Cataract Caused by High-Voltage Electrical Injury. Tw J Phys Med Rehabil 2011; 39(2): 105 – 109. (Domestic peer-reviewed journal)
Wu KP, Ke JY, Chen CY, Chen CL, Chou MY, Pei Y. Botulinum Toxin Type A on Oral Health in Treating Sialorrhea in Children with Cerebral Palsy: A Randomized Double-Blind, Placebo-Controlled Study. J of Child Neurology. 2011 Jul;26(7): 838-43.(IF: 1.39; ranked 60/121 in Pediatrics category) (Grant: NSC 94-2314-B-182A-032)
Chen C, Hsu C, Pei Y, Yu C, Chen Y, Chen C. Nocturia is an Independent Predictor of Severe Obstructive Sleep Apnea in Patients with Ischemic Stroke. Journal of Neurology. 2011 Feb;258(2):189-94. (IF: 3.58; ranked 36/191 in Clinical Neurology category) (Grant: CMRPG260581)
Liaw M, Chen C, Pei Y, Leong C, Lau Y. Comparison of the Static and Dynamic Balance Performance in Young, Middle-aged, and Elderly Healthy People. Chang Gung Med J. 2009 Jun ;32(3):297-304. (Domestic peer-reviewed journal) (Grant: NSC 89-2320-B-182A-012)
Wong A, Pei Y, Lan C, Huang S, Lin Y, Chou S. Is Tai Chi Chuan effective in improving lower limb response time to prevent backward falls in the elderly? Age (Dordr). 2009 June; 31(2):163-170. (IF: 4.08; ranked 8/46 in Geriatrics & Gerontology category) (Grant: NSC 95-2314-B-182A-005)
Pei Y, Chou S, Lin P, Lin Y, Hsu THC, Wong AMK. Eye-hand coordination of elderly people who practice Tai Chi Chuan. J Formos Med Assoc. 2008 Feb ;107(2):103-10. (IF: 1.00; ranked 78/151 in Medicine, General & Internal category). (Grant: NSC 95-2314-B-182A-005)
Yu T, Pei Y, Lau Y, Chen C, Hsu H, Wong AMK. Comparison of the effects of swimming and Tai Chi Chuan on body fat composition in elderly people. Chang Gung Med J. 2007 Mar ;30(2):128-34. (Domestic peer-reviewed journal) (Grant: NSC 95-2314-B-182A-005)
Hsieh W, Lin S, H Hsu, Wong AMK, Siu K, Pei Y*. Effect of Kinesio Taping over Frontal Region on the Attention of Normal Subjects. Tw J Phys Med Rehabil. 2006 Dec ;34(4):215-223. (Domestic peer-reviewed journal)
Wu KP, Pei Y, Liaw M, Hong W, Ke J, Wong AMK. Temporal and Kinetic Characteristics of Different Sit-to-Stand Movement Strategies in Females with Osteoporotic Vertebral Compression Fractures. Tw J Phys Med Rehabil. 2006 Sep ;34(3):129-140. (Domestic peer-reviewed journal) (Grant: NSC 89-2314-B-182A-175)
Hong W, Lee Y, Chen H, Pei Y, Wu C. Influence of heel height and shoe insert on comfort perception and biomechanical performance of young female adults during walking. Foot Ankle Int. 2005 Dec ;26(12):1042-8. (IF: 1.47; ranked 30/63 in Orthopedics category). (Grant: NSC 92-2213-E-011-041, NSC 89-2314-B-182-095)
Chou S, Abraham LD, Huang I, Pei Y, Lai C, Wong AMK. Starting position and stretching velocity effects on the reflex threshold angle of stretch reflex in the soleus muscle of normal and spastic subjects. J Formos Med Assoc. 2005 Jul ;104(7):493-501. (IF: 1.00; ranked 78/151 in Medicine, General & Internal category).
Wong AMK, Pei Y, Lui T, Chen C, Wang C, Chung C. Comparison between botulinum toxin type A injection and selective posterior rhizotomy in improving gait performance in children with cerebral palsy. J Neurosurg. 2005 May ;102(4 Suppl):385-9.(IF: 3.15; ranked 21/198 in SURGERY category). (Grant: NSC 84-2331-B-182-078)
Chou S, Pei Y, Lai C, Kuo C, Fu T, Hong W. Motor control in patients with incomplete spinal cord injuries and various voluntary movement capabilities. Chang Gung Med J. 2005 May ;28(5):349-56. (Domestic peer-reviewed journal)
Lin C, Pei Y, Chung C, Cheng P, Chen C, Wong AMK. Event-Related Potentials of Visual Spatial Attention in Healthy Subjects. Tw J Phys Med Rehabil. 2005 Mar ;33(1):19-28. (Domestic peer-reviewed journal)
Hong W, Lee Y, Tang SFT, Chen C, Liu W, Pei Y*. The Discomfort Rating and Pain Relieving Behavior in High Heel Wearers and the Clinical Implication. Tw J Phys Med Rehabil. 2005 Mar ;33(1):11-18. (Domestic peer-reviewed journal)
Wong AM, Pei Y, Hong W, Chung C, Lau Y, Chen CP. Foot contact pattern analysis in hemiplegic stroke patients: an implication for neurologic status determination. Arch Phys Med Rehabil. 2004 Oct ;85(10):1625-30. (IF: 2.36; ranked 9/63 in Rehabilitation category).
Tang SF, Chen CP, Chen MJ, Pei Y, Lau Y, Leong C. Changes in sagittal ground reaction forces after intra-articular hyaluronate injections for knee osteoarthritis. Arch Phys Med Rehabil. 2004 Jun ;85(6):951-5. (IF: 2.36; ranked 9/63 in Rehabilitation category).
Leong C, Chou S, Lin T, Pan J, Pei Y, Chu N, et al. Market Analysis for the Need of Individualized Assisted Device in Patients with Physical-mental Disabilities. Tw J Phys Med Rehabil. 2004 Mar ;32(1):1-10. (Domestic peer-reviewed journal)
Chen CPC, Chen MJL, Pei Y, Lew HL, Wong P, Tang SFT. Sagittal plane loading response during gait in different age groups and in people with knee osteoarthritis. Am J Phys Med Rehabil. 2003 Apr ;82(4):307-12. (IF: 1.73; ranked 19/63 in Rehabilitation category).
Wong AMK, Pei Y, Huang P, Cheng H, Chou S, Li C. Urinary Incontinence in Young Female Athletes of Taiwan. J Rehab Med Assoc ROC. 2002 Dec ;30(4):201-206. (Domestic peer-reviewed journal)
Pei Y, Tang SFT, Hsieh W, Chao M, Wong AMK, Chen K. Relationships between Pain, Pain Behavior, Anxiety, and Muscle Tension during Electrodiagnosis. J Rehab Med Assoc ROC. 2002 Dec ;30(4):207-215. (Domestic peer-reviewed journal)
* Corresponding author
Hiring
We welcome applicants who are interested in the neural coding the brain. The following positions are available either for short term or long term research projects:
Clinical Fellowship
This research opportunity is suitable for physicians who have received at least three-year of residency training in specialties such as Rehabilitation, Neurology or Neurosurgery. We offer projects that are translational between basic and clinical neuroscience. The specific goal for this research fellowship is to develop rigorous thinking and experimental techniques that will be beneficial for clinical research and faculty development.
Graduate student: Master and PhD students
We offer laboratory rotation training and thesis research opportunities for graduate students, including master and PhD students. Graduate students major in programs related to brain function and neural coding, such as Neuroscience, Biomedical Engineering, Rehabilitation Science, Cognitive Science and other relevant fields, are welcome to visit our laboratory to seek research positions. For more information, please contact us.
Undergraduate and med student
We also welcome undergraduate or med students who seek for short-term research experience in our lab. Every year, we have around two undergraduate students to run short-term projects to explore laboratory life. The undergraduate research aims at hand-on experience on the design and analysis of human psychophysical experiments, an approach that could enrich the college life and learn how the theory in basic science is applied to life science.
除以上參與本實驗之機會外,
本實驗室目前正招募:
(1) 碩士/學士級專任研究助理一名: 需機械,電機,電子, 醫工背景等
(2) 碩士/學士級專任研究助理一名: 需神經生理, 心理學, 生醫相關科技背景者, 具實驗動物經驗為佳
Contact us
Contact information:
Yu-Cheng Pei 裴育晟
yspeii@adm.cgmh.org.tw
phone: +886-3-3196200 ext 5610
fax: +886-3-3281200 ext 2667